Severe combined immunodeficiency, Splenomegaly

abnormal granulocyte differentiation, abnormal humoral immune response, abnormal immune system organ morphology, abnormal intraepithelial T cell morphology, abnormal intraepithelial T cell number, abnormal long bone metaphysis morphology, abnormal lymphopoiesis, abnormal memory T cell number, abnormal osteoclast morphology, abnormal osteoclast physiology, abnormal positive T cell selection, abnormal response to infection, abnormal T cell activation, abnormal T cell differentiation, abnormal T cell selection, abnormal T cell subpopulation ratio, abnormal thymocyte activation, absent T cells, arrested T cell differentiation, CNS inflammation, decreased alpha-beta T cell number, decreased B-1a cell number, decreased B-1b cell number, decreased B-2 B cell number, decreased B cell proliferation, decreased CD4-positive, alpha-beta memory T cell number, decreased CD4-positive, alpha beta T cell number, decreased CD8-positive, alpha-beta memory T cell number, decreased CD8-positive, naive alpha-beta T cell number, decreased central memory CD8 positive, alpha-beta T cell number, decreased cytotoxic T cell cytolysis, decreased DN4 thymocyte number, decreased double-positive T cell number, decreased effector memory CD4-positive, alpha-beta T cell number, decreased follicular B cell number, decreased gamma-delta intraepithelial T cell number, decreased mast cell degranulation, decreased mature B cell number, decreased memory B cell number, decreased memory T cell number, decreased NK T cell number, decreased oligodendrocyte number, decreased single-positive T cell number, decreased susceptibility to type I hypersensitivity reaction, decreased systemic arterial systolic blood pressure, decreased T cell proliferation, decreased thymocyte number, enlarged lymph nodes, hematopoietic system phenotype, immune system phenotype, increased alpha-beta T cell number, increased anti-double stranded DNA antibody level, increased B-1 B cell number, increased B-1b cell number, increased CD8-positive, alpha-beta T cell number, increased central memory CD4-positive, alpha-beta T cell number, increased central memory CD8 positive, alpha-beta T cell number, increased dendritic cell number, increased DN3 thymocyte number, increased double-negative T cell number, increased effector memory CD4-positive, alpha-beta T cell number, increased effector memory CD8-positive, alpha-beta T cell number, increased IgG2a level, increased memory T cell number, increased neutrophil cell number, increased NK cell number, increased plasma cell number, increased plasmacytoid dendritic cell number, increased single-positive T cell number, increased spleen red pulp amount, increased spleen white pulp amount, increased susceptibility to autoimmune disorder, increased susceptibility to Herpesvirales infection, increased T cell apoptosis, increased transitional stage B cell number, lethality at weaning, incomplete penetrance, no abnormal phenotype detected, premature death, spleen hyperplasia