epas1 Phenotypes

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Phenotypes

Gene Literature (5)

Nucleotides (120)

Interactants (135)

XB-GENEPAGE-981611

Gene Symbol: epas1 Gene Name: endothelial PAS domain protein 1

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Computed annotations: epas1 assayed (9 sources)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Human (3 sources): Increased hematocrit, Increased hemoglobin, Polycythemia
Mouse (43 sources): abnormal alveolar lamellar body morphology, abnormal angiogenesis, abnormal eye electrophysiology, abnormal heart right ventricle pressure, abnormal hematopoietic system physiology, abnormal hemoglobin content, abnormal lung development, abnormal lung vasculature morphology, abnormal physiological neovascularization, abnormal proerythroblast morphology, abnormal pulmonary alveolus epithelial cell morphology, abnormal retina inner nuclear layer morphology, abnormal surfactant secretion, abnormal vitelline vasculature morphology, decreased birth body size, decreased circulating iron level, decreased circulating noradrenaline level, decreased erythrocyte cell number, decreased hematocrit, decreased hemoglobin content, decreased lean body mass, decreased susceptibility to injury, decreased type II pneumocyte number, embryonic lethality during organogenesis, complete penetrance, embryonic lethality during organogenesis, incomplete penetrance, heart vascular congestion, increased circulating erythropoietin level, increased erythrocyte cell number, increased heart weight, increased pulmonary respiratory rate, increased spleen weight, increased total body fat amount, lethality throughout fetal growth and development, complete penetrance, lethality, incomplete penetrance, liver vascular congestion, neonatal lethality, complete penetrance, postnatal lethality, incomplete penetrance, prenatal lethality, complete penetrance, prenatal lethality, incomplete penetrance, preweaning lethality, complete penetrance, thick pulmonary interalveolar septum, thick ventricular wall, visceral vascular congestion [+]
View all ortholog results at Monarch