| Monarch Ortholog Phenotypes
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Human (28 sources):
Abnormality of metabolism/homeostasis,
Abnormality of the integument,
Anxiety,
Autism,
Autistic behavior,
Brachydactyly,
Bronchiolitis,
Bulbous nose,
Cellulitis,
Cerebral cortical atrophy,
Coarse facial features,
Compulsive behaviors,
Echolalia,
Febrile seizure (within the age range of 3 months to 6 years),
Generalized hypotonia,
Global developmental delay,
Hypotonia,
Intellectual disability, progressive,
Intellectual disability, severe,
Microcephaly,
Neutrophilia,
Periodontitis,
Pneumonia,
Recurrent otitis media,
Reduction of neutrophil motility,
Short foot,
Short stature,
Widow's peak
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Mouse (14 sources):
abnormal leukocyte adhesion,
abnormal lymph node primary follicle morphology,
abnormal maternal nurturing,
abnormal pulmonary alveolus wall morphology,
decreased litter size,
impaired leukocyte tethering or rolling,
increased neutrophil cell number,
lethality at weaning, incomplete penetrance,
overexpanded pulmonary alveoli,
perinatal lethality, incomplete penetrance,
[+]
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View all ortholog results at Monarch
|
Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.