| Monarch Ortholog Phenotypes
|
Human (31 sources):
Absent frontal sinuses,
Astigmatism,
Cachexia,
Congestive heart failure,
Dental crowding,
Depressed nasal bridge,
Dolichocephaly,
Dysarthria,
Frontal bossing,
Hepatomegaly,
High pitched voice,
Hypertelorism,
Hypodontia,
Hypoplastic frontal sinuses,
Hypotonia,
Intrauterine growth retardation,
J-shaped sella turcica,
Macrocephaly,
Microglossia,
Myocardial fibrosis,
Nephroblastoma,
Nevus,
Pericardial constriction,
Pigmentary retinopathy,
Reduced tendon reflexes,
Short stature,
Strabismus,
Triangular face,
Ventriculomegaly,
Weak voice,
Wide nasal bridge
[+]
|
Mouse (22 sources):
abnormal adipose tissue amount,
abnormal bone mineralization,
abnormal lean body mass,
abnormal trabecula carnea morphology,
absent germ cells,
absent oocytes,
cellular phenotype,
decreased fluid intake,
decreased food intake,
decreased locomotor activity,
decreased oocyte number,
decreased respiratory quotient,
dilated liver sinusoidal spaces,
enlarged pancreas,
improved glucose tolerance,
increased fasting circulating glucose level,
increased liver triglyceride level,
increased lymphoma incidence,
increased tumor incidence,
premature death,
small cranium,
testis degeneration
[+]
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View all ortholog results at Monarch
|
Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.