| Monarch Ortholog Phenotypes
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Human (11 sources):
Abnormality of immune system physiology,
Bronchiectasis,
Fever,
Immunodeficiency,
Lymphadenopathy,
Oral ulcer,
Pneumonia,
Recurrent infections,
Recurrent respiratory infections,
Sinusitis,
[+]
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Mouse (36 sources):
abnormal cytotoxic T cell physiology,
abnormal definitive hematopoiesis,
abnormal erythropoiesis,
abnormal humoral immune response,
abnormal megakaryocyte morphology,
abnormal myelopoiesis,
abnormal plasma cell number,
abnormal sleep behavior,
abnormal spleen marginal zone morphology,
decreased bone mineral content,
decreased fasting circulating glucose level,
decreased follicular B cell number,
decreased interferon-gamma secretion,
decreased macrophage cell number,
enlarged lymph nodes,
immune system phenotype,
increased B-1b cell number,
increased B-2 B cell number,
increased CD4-positive, alpha beta T cell number,
increased bone marrow cell number,
increased follicular B cell number,
increased granulocyte number,
increased lymphoma incidence,
increased macrophage cell number,
increased marginal zone B cell number,
increased mature B cell number,
increased neutrophil cell number,
increased prepulse inhibition,
increased sensitivity to induced morbidity/mortality,
increased spleen red pulp amount,
increased spleen weight,
increased susceptibility to Riboviria infection,
increased transitional stage B cell number,
no abnormal phenotype detected,
premature death,
spleen hyperplasia
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View all ortholog results at Monarch
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Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.