| Monarch Ortholog Phenotypes
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Human (27 sources):
Abnormal cortical gyration,
Areflexia,
Arthrogryposis multiplex congenita,
Axonal loss,
Barrett esophagus,
Decreased fetal movement,
Dysphagia,
Esophageal carcinoma,
Esophageal ulceration,
Flexion contracture,
Gastroesophageal reflux,
Generalized hypotonia,
Global developmental delay,
Increased variability in muscle fiber diameter,
Multiple prenatal fractures,
Muscle weakness,
Neonatal respiratory distress,
Patent ductus arteriosus,
Patent foramen ovale,
Peripheral axonal neuropathy,
Polyhydramnios,
Premature birth,
Pulmonary hypoplasia,
Respiratory insufficiency,
Severe muscular hypotonia,
Skeletal muscle atrophy,
Spinal muscular atrophy
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Mouse (3 sources):
abnormal body wall morphology,
abnormal embryo size,
preweaning lethality, incomplete penetrance
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View all ortholog results at Monarch
|
Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.