| Monarch Ortholog Phenotypes
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Human (64 sources):
Abnormal choroid morphology,
Abnormal electroretinogram,
Abnormal retinal vascular morphology,
Abnormal testis morphology,
Abnormality of chorioretinal pigmentation,
Abnormality of fundus pigmentation,
Abnormality of retinal pigmentation,
Abnormality of the orbital region,
Abnormality of vision,
Anteverted nares,
Attenuation of retinal blood vessels,
Atypical scarring of skin,
Blindness,
Cataract,
Choroideremia,
Color vision defect,
Conductive hearing impairment,
Constriction of peripheral visual field,
Cystoid macular degeneration,
Decreased light- and dark-adapted electroretinogram amplitude,
Dyschromatopsia,
Glaucoma,
High hypermetropia,
Hyperinsulinemia,
Hypermetropia,
Hyperreflexia,
Hypogonadism,
Hypoplasia of penis,
Intellectual disability,
Iris hypopigmentation,
Keratoconus,
Macular dystrophy,
Metamorphopsia,
Microcornea,
Microphthalmia,
Nyctalopia,
Nystagmus,
Obesity,
Ophthalmoplegia,
Optic atrophy,
Optic disc pallor,
Photophobia,
Pigmentary retinopathy,
Posterior staphyloma,
Progressive night blindness,
Pulverulent cataract,
Reduced visual acuity,
Retinal arteriolar constriction,
Retinal arteriolar occlusion,
Retinal detachment,
Retinal flecks,
Retinal neovascularization,
Retinal nonattachment,
Retinal pigment epithelial atrophy,
Rod-cone dystrophy,
Sensorineural hearing impairment,
Strabismus,
Subretinal fluid,
Type II diabetes mellitus,
Visual field defect,
Visual impairment,
Vitelliform-like macular lesions,
Vitreous hemorrhage,
Wide nasal bridge
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Mouse (16 sources):
abnormal acrosome morphology,
abnormal eye electrophysiology,
abnormal retina pigment epithelium morphology,
abnormal sperm flagellum morphology,
abnormal sperm physiology,
absent acrosome,
asthenozoospermia,
coiled sperm flagellum,
decreased litter size,
detached sperm flagellum,
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View all ortholog results at Monarch
|
Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.