kcnh6 Phenotypes

Summary

Expression

Phenotypes

XB-GENEPAGE-990942

Gene Symbol: kcnh6 Gene Name: potassium channel, voltage gated eag related subfamily H, member 6

Anatomical Phenotypes Phenotypes manually curated with terms from the Xenopus phenotype ontology covering anatomical, gene ontology, and neurobehavioral phenotypes.
abnormal gastrulation (6 sources), abnormal blastopore morphology (3 sources), abnormal foregut morphology (2 sources), abnormal heart looping (2 sources), abnormal left-right axis morphology (2 sources), abnormal calcium ion transport (1 source), abnormal gall bladder (1 source), abnormal gastrocoel roof plate morphology (1 source), abnormal intestine morphology (1 source), abnormal mesoderm (1 source), abnormally delayed closure of blastopore (1 source), absent paraxial mesoderm (1 source), increased size of the heart (1 source)

Anatomical Phenotypes

Phenotypes manually curated with terms from the Xenopus phenotype ontology covering anatomical, gene ontology, and neurobehavioral phenotypes.

abnormal gastrulation (6 sources), abnormal blastopore morphology (3 sources), abnormal foregut morphology (2 sources), abnormal heart looping (2 sources), abnormal left-right axis morphology (2 sources), abnormal calcium ion transport (1 source), abnormal gall bladder (1 source), abnormal gastrocoel roof plate morphology (1 source), abnormal intestine morphology (1 source), abnormal mesoderm (1 source), abnormally delayed closure of blastopore (1 source), absent paraxial mesoderm (1 source), increased size of the heart (1 source)

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Manual annotations: kcnh6 manipulated (16 sources)

Diseases Diseases from the human disease ontology (DO) manually associated with phenotypes from disease models. Sources are grouped by anatomical (AP) and expression (EP) phenotypes.
situs inversus (2AP sources)

Experiments (Reagents) These are short form descriptions of experiments using reagents targeting the gene of interest.
Xtr Wt + kcnh6 CRISPR (400pg) (15 sources), Xtr Wt + kcnh6 MO (6 sources), Xtr Wt + cacna1c CRISPR + kcnh6 MO (2 sources), Xtr Wt + kcnh6 CRISPR + choline (1 source)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Mouse (16 sources): abnormal action potential, abnormal calcium ion homeostasis, abnormal circulating total protein level, abnormal insulin secretion, abnormal kidney morphology, abnormal pancreatic beta cell physiology, decreased channel response intensity, decreased circulating glucose level, decreased insulin secretion, decreased pancreatic beta cell mass, increased endoplasmic reticulum stress, increased fasting circulating glucose level, increased insulin secretion, increased pancreatic alpha cell number, increased pancreatic islet cell apoptosis, pancreas necrosis [+]

Monarch Ortholog Phenotypes

These phenotypes are associated with this gene with a has phenotype relation via Monarch.

Mouse (16 sources): abnormal action potential, abnormal calcium ion homeostasis, abnormal circulating total protein level, abnormal insulin secretion, abnormal kidney morphology, abnormal pancreatic beta cell physiology, decreased channel response intensity, decreased circulating glucose level, decreased insulin secretion, decreased pancreatic beta cell mass, [+]