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XB-GENEPAGE-992884
aldh1a3 aldehyde dehydrogenase 1 family member A3
Anatomical Phenotypes
Phenotypes manually curated with terms from the Xenopus phenotype ontology
covering anatomical, gene ontology, and neurobehavioral phenotypes.
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| decreased size of the head (2 sources), abnormal development of eye (1 source), decreased size of the cement gland (1 source) |
| Expression Phenotypes
Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.
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| Manual annotations: aldh1a3 manipulated (1 source), aldh1a3 assayed (8 sources) |
| Computed annotations: aldh1a3 assayed (2 sources) |
| Diseases
Diseases from the human disease ontology (DO) manually associated with phenotypes
from disease models. Sources are grouped by anatomical (AP) and expression (EP) phenotypes.
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| microcephaly (2AP sources) |
| Experiments (Reagents)
These are short form descriptions of experiments using reagents targeting
the gene of interest.
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| Xla Wt + cyp26a1 + aldh1a3 MO (2 sources), Xla Wt + aldh1a3 CRISPR (1 source) |
| Monarch Ortholog Phenotypes
These phenotypes are associated with this gene with a has phenotype relation via Monarch.
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| Human (5 sources): Coloboma, Entropion, Microphthalmia, Optic nerve hypoplasia, Retinal detachment |
| Mouse (18 sources): abnormal locomotor activation, abnormal locomotor behavior, abnormal nasal cavity morphology, abnormal periocular mesenchyme morphology, abnormal vitreous body morphology, absent Harderian gland, absent maxillary sinus, absent nasolacrimal duct, decreased periocular mesenchyme apoptosis, decreased ventral retina size, [+] |
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View all ortholog results at Monarch |