| Monarch Ortholog Phenotypes
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Human (34 sources):
Abnormality of the pinna,
Ambiguous genitalia,
Anteriorly placed anus,
Astigmatism,
Atrial septal defect,
Chiari malformation,
Coarctation of aorta,
Coarse facial features,
Cryptorchidism,
Cupped ear,
Epicanthus,
Flat acetabular roof,
Gait imbalance,
Generalized hypotonia,
Hearing impairment,
Hypertelorism,
Intellectual disability,
Low-set ears,
Macrocephaly,
Micropenis,
Ptosis,
Renal insufficiency,
Short clavicles,
Short femoral neck,
Short palpebral fissure,
Short stature,
Tapered finger,
Tetralogy of Fallot,
Trigonocephaly,
Upslanted palpebral fissure,
Ventricular septal defect,
Ventriculomegaly,
Vesicoureteral reflux,
Wormian bones
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Mouse (14 sources):
abnormal CD4-positive, alpha beta T cell morphology,
abnormal T cell differentiation,
abnormal extraembryonic tissue physiology,
absent blastocoele,
arrested T cell differentiation,
decreased T cell proliferation,
decreased double-positive T cell number,
embryonic lethality before implantation, complete penetrance,
embryonic lethality prior to organogenesis,
embryonic lethality, complete penetrance,
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View all ortholog results at Monarch
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Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.