| Monarch Ortholog Phenotypes
|
Human (44 sources):
Acute infectious pneumonia,
Arrhythmia,
Bronchiectasis,
Cachexia,
Cerebral ischemia,
Chest pain,
Chronic bronchitis,
Clubbing,
Constipation,
Crackles,
Dehydration,
Diarrhea,
Dyspnea,
Elevated sweat chloride,
Emphysema,
Failure to thrive,
Fatigue,
Feeding difficulties in infancy,
Fever,
Halitosis,
Hemoptysis,
Hyperactive renin-angiotensin system,
Hyperkalemia,
Hypertension,
Hypokalemia,
Hyponatremia,
Hypotension,
Increased circulating aldosterone concentration,
Metabolic acidosis,
Muscle weakness,
Myocardial infarction,
Nephropathy,
obsolete Decreased pulmonary function,
Productive cough,
Pseudohypoaldosteronism,
Recurrent Haemophilus influenzae infections,
Recurrent lower respiratory tract infections,
Recurrent respiratory infections,
Reduced FEV1/FVC ratio,
Renal insufficiency,
Renal salt wasting,
Respiratory tract infection,
Vomiting,
Wheezing
[+]
|
|
Mouse (5 sources):
abnormal renal transport,
decreased locomotor activity,
neonatal lethality, complete penetrance,
no abnormal phenotype detected,
preweaning lethality, complete penetrance
|
View all ortholog results at Monarch
|
Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.