The flcn gene encodes a tumor suppressor protein functioning as a gtpase-activating protein for ragc in the mtorc1 signaling pathway. The protein localizes to the nucleus and cytoplasm. It is involved ...[+]

The flcn gene encodes a tumor suppressor protein functioning as a gtpase-activating protein for ragc in the mtorc1 signaling pathway. The protein localizes to the nucleus and cytoplasm. It is involved in left-right patterning, with knockdown causing right isomerism of the lungs and randomization of heart looping and gut coiling. Expression is detected in the brain, branchial arches, eye, otic vesicle, pronephros, notochord, and tailbud during development. [-]

             Birt-Hogg-Dube syndrome
             Potocki-Lupski syndrome
             colorectal cancer
             primary spontaneous pneumothorax

          RENAL CELL CARCINOMA, NONPAPILLARY; RCC
          BIRT-HOGG-DUBE SYNDROME 1; BHD1
          PNEUMOTHORAX, PRIMARY SPONTANEOUS; PSP
          POTOCKI-LUPSKI SYNDROME; PTLS

ClinVar, ClinGen, MalaCards, KEGG Disease, DECIPHER, COSMIC, MARRVEL, GTR, DisGeNET, dbVAR, GHR, gnomAD