The tpm1 gene encodes a tropomyosin protein that functions in actin filament binding and is involved in skeletal and cardiac muscle contraction in Xenopus laevis and Xenopus tropicalis. It is expressed...[+]

The tpm1 gene encodes a tropomyosin protein that functions in actin filament binding and is involved in skeletal and cardiac muscle contraction in Xenopus laevis and Xenopus tropicalis. It is expressed in skeletal muscle, cardiac muscle, and smooth muscle tissues. The protein localizes to the thin filaments of the sarcomere and is essential for muscle contraction. [-]

             hypertrophic cardiomyopathy 3
             dilated cardiomyopathy 1Y

          CARDIOMYOPATHY, DILATED, 1Y; CMD1Y

ClinVar, ClinGen, MalaCards, KEGG Disease, DECIPHER, COSMIC, MARRVEL, GTR, DisGeNET, dbVAR, GHR, gnomAD