The gene prkcz encodes a protein kinase c zeta type serine/threonine-protein kinase. It is involved in meiotic maturation and oocyte polarization through the regulation of cytoplasmic streaming and cor...[+]

The gene prkcz encodes a protein kinase c zeta type serine/threonine-protein kinase. It is involved in meiotic maturation and oocyte polarization through the regulation of cytoplasmic streaming and cortical rotation, impacting dorsal axis formation. The protein localizes to the cytoplasm and nucleus. During early development, it is expressed in the animal hemisphere, dorsal marginal zone, notochord, somites, brain including the forebrain, midbrain, and hindbrain, spinal cord, neural tube, eye, branchial arches, and pronephros. [-]

ClinVar, ClinGen, MalaCards, KEGG Disease, DECIPHER, COSMIC, MARRVEL, GTR, DisGeNET, dbVAR, GHR, gnomAD