The cdc34 gene encodes an E2 ubiquitin-conjugating enzyme. This protein functions in the ubiquitin-proteasome pathway to regulate cell cycle progression, specifically targeting proteins for degradation...[+]

The cdc34 gene encodes an E2 ubiquitin-conjugating enzyme. This protein functions in the ubiquitin-proteasome pathway to regulate cell cycle progression, specifically targeting proteins for degradation during the G1 to S phase transition. It is involved in the embryonic cell cycles and is expressed in oocytes and early embryos. The cdc34 protein localizes to the nucleus and cytoplasm. [-]

ClinVar, ClinGen, MalaCards, KEGG Disease, DECIPHER, COSMIC, MARRVEL, GTR, DisGeNET, dbVAR, GHR, gnomAD