The sdc4 gene encodes a transmembrane heparan sulfate proteoglycan core protein that localizes to the cell membrane. Its function involves presenting heparan sulfate chains to bind signaling molecules ...[+]

The sdc4 gene encodes a transmembrane heparan sulfate proteoglycan core protein that localizes to the cell membrane. Its function involves presenting heparan sulfate chains to bind signaling molecules such as FGF2 and sonic hedgehog (SHH). This activity is implicated in regulating neural crest cell migration and contributes to the proper formation of cranial ganglia. [-]

ClinVar, ClinGen, MalaCards, KEGG Disease, DECIPHER, COSMIC, MARRVEL, GTR, DisGeNET, dbVAR, GHR, gnomAD