The ccny gene encodes a cyclin protein that functions as a regulatory subunit for cyclin-dependent kinases such as CDK14 and CDK16. This complex is involved in the Wnt signaling pathway, where it regul...[+]

The ccny gene encodes a cyclin protein that functions as a regulatory subunit for cyclin-dependent kinases such as CDK14 and CDK16. This complex is involved in the Wnt signaling pathway, where it regulates the transcription factor LEF1. The protein localizes to the cytoplasm and nucleus and is implicated in cell cycle progression. Expression is observed during development in the eye, brain, spinal cord, and branchial arches, with roles in neurulation and photoreceptor maintenance. [-]

ClinVar, ClinGen, MalaCards, KEGG Disease, DECIPHER, COSMIC, MARRVEL, GTR, DisGeNET, dbVAR, GHR, gnomAD