The prohibitin-1 protein functions as a scaffold and chaperone protein involved in mitochondrial inner membrane organization and stabilization of mitochondrial DNA. It is localized to the mitochondria,...[+]

The prohibitin-1 protein functions as a scaffold and chaperone protein involved in mitochondrial inner membrane organization and stabilization of mitochondrial DNA. It is localized to the mitochondria, nucleus, and cell membrane. The protein interacts with specific mrna transcripts during oogenesis and early development, influencing cell proliferation and apoptosis. Expression is documented in the ovary, testis, eye, brain, spinal cord, neural tube, notochord, somites, branchial arches, heart, pronephros, liver, and intestine. [-]

ClinVar, ClinGen, MalaCards, KEGG Disease, DECIPHER, COSMIC, MARRVEL, GTR, DisGeNET, dbVAR, GHR, gnomAD