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Summary Expression Phenotypes Gene Literature (17) GO Terms (5) Nucleotides (59) Proteins (36) Interactants (188) Wiki
XB-GENEPAGE-1221136
Gene Symbol:
 invs

Gene Name: 
inversin

Synonyms:
NPH2 , NPHP2 , inversin , nephrocystin-2 , invs-a , invs-b [+] ( Nomenclature history )

Gene Function:
multiple ankyrin domains and two IQ calmodulin-binding domains: functions in cilia formation and left-right axis establishment

Protein Function :
Required for normal renal development and establishment of left-right axis. Probably acts as a molecular switch between different Wnt signaling pathways. Inhibits the canonical Wnt pathway by targeting...[+]


InterPro :
CNKSR2 , SAM , PDZ , PDZ sf [+]

Interactants:
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Diseases: 


Disease Ontology:
Senior-Loken syndrome [+]

OMIM:
NEPHRONOPHTHISIS 2; NPHP2

External Links:
 
Expression                  Development Stages                                               Embryonic Tissues                                                                Adult Tissues
More Information
Xenbase Expression Details In situ images Single cell data at SPRING In situ: RNA-Seq:


Symbol legend: Blast sequence    View sequence    Literature or expression images   Hover cursor for info