Gene Symbol:  rtn2 Gene Name:  reticulon 2 Synonyms: xrtn2 ( Nomenclature history ) Gene Function: Reticulon Protein Function : Inhibits amyloid precursor protein processing, probably by blocking BACE1 activity. Enhances trafficking of the glutamate transporter SLC1A1/EAAC1 from the endoplasmic reticulum to the cell surface. Pl...[+] Inhibits amyloid precursor protein processing, probably by blocking BACE1 activity. Enhances trafficking of the glutamate transporter SLC1A1/EAAC1 from the endoplasmic reticulum to the cell surface. Plays a role in the translocation of SLC2A4/GLUT4 from intracellular membranes to the cell membrane which facilitates the uptake of glucose into the cell. [-] InterPro : CSN8 PSD8 EIF3K , PCI dom , COP9 CSN8 , Reticulon Interactants: Loading ... Diseases:  Disease Ontology: hereditary spastic paraplegia 12 OMIM: SPASTIC PARAPLEGIA 12, AUTOSOMAL DOMINANT; SPG12 External Links: ClinVar, ClinGen, MalaCards, KEGG Disease, DECIPHER, COSMIC, MARRVEL, GTR, DisGeNET, dbVAR, GHR, gnomAD

Expression	Development Stages                                               Embryonic Tissues                                                                Adult Tissues
More Information	Xenbase Expression Details In situ images Single cell data at SPRING

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