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Summary Expression Phenotypes Gene Literature (9) GO Terms (5) Nucleotides (88) Proteins (34) Interactants (63) Wiki
Gene Symbol:

Gene Name: 
apoptotic peptidase activating factor 1

apaf-1 ( Nomenclature history )

Gene Function:
apoptosis/apoptosome scaffold protein with WD-40 domains, caspase recruitment domain (CARD), and an ATPase domain

Protein Function :
Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.

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External Links:
Expression                  Development Stages                                               Embryonic Tissues                                                                Adult Tissues
More Information
Xenbase Expression Details In situ images Single cell data at SPRING In situ: RNA-Seq:

Symbol legend: Blast sequence    View sequence    Literature or expression images   Hover cursor for info