|
Display additional annotations [+]
Gene |
Clone |
Species |
Stages |
Anatomy |
rbpms2
|
|
laevis
|
NF stage 33 and 34
|
retina
,
pronephric duct
,
heart
,
eye
,
pronephric nephron
,
[+]
|
elavl3
|
|
laevis
|
NF stage 33 and 34
|
olfactory placode
,
retina
,
brain
,
forebrain
,
midbrain
,
[+]
hindbrain
,
midbrain-hindbrain boundary
,
eye
,
epibranchial placode
,
dorsal
,
trigeminal ganglion
,
cranial nerve
,
trigeminal nerve
,
facial nerve
,
glossopharyngeal nerve
,
vagus nerve
|
ebf3
|
|
laevis
|
NF stage 33 and 34
|
olfactory placode
,
otic vesicle
,
retina
,
brain
,
forebrain
,
[+]
midbrain
,
hindbrain
,
midbrain-hindbrain boundary
,
pharyngeal arch
,
mandibular arch
,
hyoid arch
,
branchial arch
,
eye
,
epibranchial placode
,
cranial nerve
,
lateral line placode
,
thyroid primordium
,
facial nerve
,
glossopharyngeal nerve
,
vagus nerve
|
pou4f4
|
|
laevis
|
NF stage 33 and 34
|
otic vesicle
,
retina
,
midbrain
,
midbrain-hindbrain boundary
,
eye
,
[+]
|
vxn
|
|
laevis
|
NF stage 33 and 34
|
retina
,
hindbrain
,
midbrain-hindbrain boundary
,
eye
|
|
|
Fig. 4. Sox2 blocks neuronal differentiation downstream of the proneural genes. (A,B) Overexpression of Sox2 in retinal progenitors by mRNA injection at the 8-cell stage does not decrease the expression of the proneural gene Xath5 on the injected side (B), as compared with the control side (A), in stage 34 embryos. (C-L) Retinal expression of the proneural targets Brn3d (C,D), Ebf3 (E,F), ElrC (G,H) and Sbt1 (I, J) is lost, as compared with the control (uninjected) side of the embryos. Sox2-injected embryos also lose retinal expression of Hermes (K,L), a marker of differentiated ganglion cells. Brackets indicate the retina. |