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atoh7xenopus   

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Experiment details for atoh7

A directional Wnt/beta-catenin-Sox2-proneural pathway regulates the transition from proliferation to differentiation in the X...

A directional Wnt/beta-catenin-Sox2-proneural pathway regulates the transition from proliferation to differentiation in the Xenopus retina.

Gene Clone Species Stages Anatomy
atoh7.S laevis NF stage 33 and 34 otic vesicle , retina , brain , eye

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  Fig. 2. Canonical Wnt signaling does not affect retinal identity but blocks neuronal differentiation downstream of the proneural genes. (A,B) Rx:Act-β-catenin (Act β-cat) transgenic embryos (stage 23) show normal expression of Rx and En (A) and of the retinal progenitor marker Vsx1 (B). (C,D) Act β-cat transgenic embryos show normal expression of Sox2 (C), a gene required for neural competence, and of the neurogenic gene Notch (D). (E,F) Actβ -cat transgenic embryos (stage 34) show normal expression of the proneural gene Xath5. (G-P) Act β-cat transgenic embryos show loss of retinal expression of the proneural target genes Brn3D (G,H), Ebf3 (I,J), ElrC (K,L) and Sbt1 (M,N), as well as of Hermes (O,P), a marker of differentiated ganglion cells. Brackets indicate the retina.