|
Display additional annotations [+]
Gene |
Clone |
Species |
Stages |
Anatomy |
rbpms2
|
|
laevis
|
NF stage 33 and 34
|
retina
,
brain
,
pronephric duct
,
heart
,
eye
,
[+]
|
elavl3
|
|
laevis
|
NF stage 33 and 34
|
olfactory placode
,
otic vesicle
,
retina
,
brain
,
forebrain
,
[+]
|
ebf3
|
|
laevis
|
NF stage 33 and 34
|
olfactory placode
,
otic vesicle
,
retina
,
brain
,
forebrain
,
[+]
midbrain
,
hindbrain
,
midbrain-hindbrain boundary
,
pharyngeal arch
,
mandibular arch
,
hyoid arch
,
branchial arch
,
eye
,
cranial nerve
,
lateral line placode
,
thyroid primordium
,
glossopharyngeal nerve
,
vagus nerve
|
pou4f4
|
|
laevis
|
NF stage 33 and 34
|
otic vesicle
,
retina
,
midbrain
,
midbrain-hindbrain boundary
,
eye
,
[+]
|
vxn
|
|
laevis
|
NF stage 33 and 34
|
retina
,
midbrain
,
hindbrain
,
midbrain-hindbrain boundary
,
eye
|
|
|
Fig. 2. Canonical Wnt signaling does not affect retinal identity but blocks neuronal differentiation downstream of the proneural genes. (A,B) Rx:Act-β-catenin (Act β-cat) transgenic embryos (stage 23) show normal expression of Rx and En (A) and of the retinal progenitor marker Vsx1 (B). (C,D) Act β-cat transgenic embryos show normal expression of Sox2 (C), a gene required for neural competence, and of the neurogenic gene Notch (D). (E,F) Actβ -cat transgenic embryos (stage 34) show normal expression of the proneural gene Xath5. (G-P) Act β-cat transgenic embryos show loss of retinal expression of the proneural target genes Brn3D (G,H), Ebf3 (I,J), ElrC (K,L) and Sbt1 (M,N), as well as of Hermes (O,P), a marker of differentiated ganglion cells. Brackets indicate the retina. |