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atoh7xenopus forebrain 

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Experiment details for atoh7

Agathocleous M et al. (2009) Assay

A directional Wnt/beta-catenin-Sox2-proneural pathway regulates the transition from proliferation to differentiation in the Xenopus retina.

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Gene Clone Species Stages Anatomy
atoh7.S laevis NF stage 33 and 34 forebrain

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  Fig. 4. Sox2 blocks neuronal differentiation downstream of the proneural genes. (A,B) Overexpression of Sox2 in retinal progenitors by mRNA injection at the 8-cell stage does not decrease the expression of the proneural gene Xath5 on the injected side (B), as compared with the control side (A), in stage 34 embryos. (C-L) Retinal expression of the proneural targets Brn3d (C,D), Ebf3 (E,F), ElrC (G,H) and Sbt1 (I, J) is lost, as compared with the control (uninjected) side of the embryos. Sox2-injected embryos also lose retinal expression of Hermes (K,L), a marker of differentiated ganglion cells. Brackets indicate the retina.