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Fig. 5. Spatial analyses of cadherin-5 expression. Whole-mount in situ hybridization of wild type embryos at developmental stages 27 to 37. Earliest cdh5 expression was detectable at NF stage 27 when first vascular structures developed. Subsequently cdh5 expression could be detected in all newly formed vascular structures. The tissue of a NF stage 37 embryo was cleared before pictures were taken. Abbreviations: (aa) aortic arches, (da) dorsal aorta, (dc) duct of cuvier, (dlav) dorsal longitudinal anastomosing vessel, (ha) heart anlage, (isv) intersomitic veins, (pcv) posterior cardinal vein, (rv) retinal vein, (vv) vitelline veins. |