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Fig. 2. Spatial expression pattern of RHAMM mRNA in early Xenopus laevis embryos. (A) RHAMM maternal transcript is distributed in the animal pole blastomeres (arrow) of a blastula stage embryo (st. 6). (B) RHAMM mRNA distribution during gastrulation (st. 10.5) (arrow). (C) Specific expression of RHAMM mRNA in the neural tube (nt) and anterior neural plate of a neurula stage embryo (st. 17), frontal view. (D) Double in situ hybridization visualizing the pre-migratory cranial NCC by the gene expression of Sox9 (light blue) and RHAMM in the neural tube (dark blue). (E) Frontal view of a stage 20 embryo exhibiting RHAMM transcript localization in the eye field (e), in the neural tube (nt) and in the otic placodes (op). |