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Fig. 2. Voltage-dependent potassium 1.3 (Kv1.3)–like subunits are
expressed in the Xenopus retina. Transverse sections through the
Xenopus retina at different developmental stages were immunostained
with a rabbit antibody against the C-terminus of the human
Kv1.3 subunit. A: At stage 32, cells in the neuroepithelium of the
retina and brain are immunopositive. B: At stage 37/38, retinal ganglion
cells (RGCs) and their processes along the vitreal surface are
labelled, as are the inner and outer plexiform layers (IPL and OPL)
and the ciliary marginal zone (CMZ). C,E: By stage 40, the optic nerve
head and optic nerve are brightly labelled. D: Almost no labelling is
observed when the Kv1.3 subunit antibody is preincubated with a
control Kv1.3 subunit peptide antigen. Similar low power sections are
shown in C and D. Br, brain; D, dorsal; L, lens; NP, neuropil; on, optic
nerve; onh, optic nerve head; PE, pigmented epithelium; RGCL, retinal
ganglion cell layer; V, ventral; vs, vitreal surface. Scale bar 50
m for A, B, and E and 100 m for C and D. |