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nrxn3xenopus   

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Experiment details for nrxn3

The expression and alternative splicing of alpha-neurexins during Xenopus development.

The expression and alternative splicing of alpha-neurexins during Xenopus development.

Gene Clone Species Stages Anatomy
nrxn3.L laevis unfertilized egg stage oocyte , stage I oocyte , stage II oocyte , stage III oocyte , stage IV oocyte , [+]
nrxn3.L laevis NF stage 66 ovary

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  Fig. 3. Transcripts of α-neurexins are expressed in Xenopus oocytes. Ovarian tissue consisting of connective tissue, follicle cells and oocytes at different stages of development was subject to wholemount in situ hybridisation using probes specific for each of the neurexin transcripts. (A) An nrxn I specific probe identifies transcripts equally distributed through small, early stage oocytes (yellow arrows). At later stages, the nrxn Iα transcript is localised to a crescent within the large oocyte (red arrows). Transcripts were not detected in cells other than oocytes. (B,C) Nrxn II (B) and nrxn III (C) transcripts were found in all stages of oocyte. At the later stages, in the large oocyte, the signal is less intense probably due to the dilution of the mRNA in the larger cytoplasmic volume. There was no evidence for localisation of these transcripts and neither were they detected in cells other than oocytes. Right-hand-side panels: negative controls, hybridised with corresponding sense neurexin cRNA probes

Gene Clone Species Stages Anatomy
nrxn3.L laevis NF stage 24 eye , posterior neural tube , Rohon-Beard neuron , neuron
nrxn3.L laevis NF stage 32 diencephalon , midbrain , spinal cord , pineal gland , unspecified , [+]

  Fig. 5 (Left). Nrxn III α is expressed in a subset of neural cells. (A,B) In situ hybridisation with an α-nrxn III-specific probe identifies a row of primary neurons at stage 24 (A), that lies either side of the midline towards the anterior end of the embryo. (C) By the tailbud stage, expression resolves into two stripes either side of the midline (red and green arrows). Those arrowed in red are located in the position expected for primary interneurons. The second band is located more ventrally. Within the head there are discrete areas of expression (yellow arrows). (D,E) Transverse sections at the level of the hindbrain (D) and anterior spinal cord (E). nrxnIIIα expression (red arrows) is restricted to the lateral neural tube.

Gene Clone Species Stages Anatomy
nrxn3.L laevis NF stage 32 retina , brain , forebrain , midbrain , hindbrain , [+]

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  Fig.4. Expression of α-neurexins is predominantly in neural tissue in the tailbud embryo. (A,B) In situ hybridisation with a nrxn Iα probe showing whole embryo (A) and an anterior neural section (B). Nrxn I is found in cells along the length of the CNS but with a distinct gap at the midbrain-hindbrain boundary. Sections show expression in the dorsolateral neural tube and within the eye. (C,D) Embryos hybridised with a nrxn IIα-specific probe show a similar pattern of staining to that seen with nrxn I. (E,F) Embryos hybridised with a nrxn IIIα-specific probe show much more restricted expression in the CNS and in section show ventrolateral and eye expression in the anterior CNS (arrows).

Gene Clone Species Stages Anatomy
nrxn3.L laevis NF stage 32 diencephalon , midbrain , spinal cord , pineal gland , central nervous system , [+]

  nrxn3 (neurexin 3) gene expression in Xenopus laevis embryo as assayed by in situ hybridization, NF stage 32. Lateral view: Dorsal up, anterior left.