• Phenotypes on Xenbase

    The latest release of Xenbase includes the ability to search for Phenotypes.

     

    Click here to go to the Phenotype search page.

     

    Click here to find details on executing a Phenotype search.

     

    Click here to find details on the Xenopus Phenotype Ontology (XPO).

     

     

    Read More...
  • Xenbase Winter Newsletter 2020

    Please follow this link to the Xenbase Winter Newsletter 2020.

     

    Read the PDF for more details.

     

    The newsletter archive can be found here.

     

     

    Read More...
  • Xenbase v5.0

    Release v5.0 of Xenbase is now available.

    Among the latest improvements are:

    - Phenotypes
    - X. tropicalis genome v10.0 integration
    - Redesigned homepage

    Stay safe!

    Read More...
  • Epigenetic sperm programming

    Sperm contribute genetic and epigenetic information to the embryo. Oikawa et al. published in Nature Communications show homogeneously methylated histone H3 at the same genomic locations in most sperm cells.

    Read More...
  • A regeneration-permissive environment requires myeloid cells following tail amputation

    Aztekin et al. interrogated natural tail regeneration during regeneration-competent and -incompetent developmental stages finding the myeloid lineage is essential for regeneration. Find their study at Development.

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  • GSK3 Inhibits Macropinocytosis and Lysosomal Activity through the Wnt Destruction Complex Machinery

    Albrecht et al. publish in Cell Reports Wnt-induced macropinocytosis is regulated through glycogen synthase kinase 3 (GSK3) and the β-catenin destruction complex.

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  • Roles of NMDARs in Visual Circuit Development

    Kesner et al. publish in Cell Reports that N-methyl-D-aspartate receptors (NMDARs) on post- and presynaptic neurons regulate neuronal morphology in opposing manners.

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  • Predation threats over 24 hours activate extension of axons in tadpole brains

    Mori et al. investigated the induced gene expression and axon morphology changes in the brains of tadpoles under the threat of predation. Published in Scientific Reports.

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  • Professor Anna Philpott elected member of EMBO

    Dr. Anna Philpott of the University of Cambridge elected to membership of the European Molecular Biology Organization (EMBO) for 2020.

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  • Long-term transcription factor binding stabilizes gene expression

    Gurdon et al., published in PNAS, show that long-term (hours to days as opposed to seconds) non-competitive binding of transcription factors such as neurogenic Ascl1 stabilizes gene expression.

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  • Autism risk gene dyrk1a is required for ciliogenesis and brain size

    Willsey & Xu et al., using X. tropicalis, show that mutations in the neurodevelopmental disorder risk gene, dyrk1a, disrupts cell cycle progression and ciliogenesis causing brain defects. Published in Development.

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  • 18th International Xenopus Conference

    The meeting has been postponed to August 15-19, 2021.

    Portsmouth, UK at the EXRC

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  • GBrowse on Xenbase

    Archived genomes viewable on GBrowse.

    As well as...

    X. laevis v9.2

    X. tropicalis v9.1 and v10.0

    Click "read more" on how to access archived genomes on Xenbase GBrowse:

     

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  • Xenopus tropicalis v10 genome

    - available to BLAST

    - view on JBrowse

     

    99.86% of the genome mapped to chromosomes
    ~4500 new and refined models, 18% not present in trop v9.1

     

    Click here to view the release document.

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  • 2020 Xenopus White Paper

    The 2020 Xenopus Community White Paper is now available!

    PIs: Please reference the White Paper in your NIH grant proposals and contact your program officers.

    Download the 2020 Xenopus White Paper:

    Word Document

    PDF

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  • Phenotypes on Xenbase

    The latest release of Xenbase includes the ability to search for Phenotypes.

     

    Click here to go to the Phenotype search page.

     

    Click here to find details on executing a Phenotype search.

     

    Click here to find details on the Xenopus Phenotype Ontology (XPO).

     

     

    Read More...

Xenopus is an essential vertebrate model system for biomedical research

  • Share 83% human disease genes
  • Ease of genomic manipulation
  • Large eggs and embryos with rapid external development
  • Ease of housing
  • Produce hardy eggs year-round
  • Learn more about Xenopus


The Xenopus model organism knowledgebase
Xenbase is an essential web-accessible resource that integrates all the diverse biological, genomic, genotype and phenotype data available from Xenopus research. Learn more about Xenbase.