• 18th International Xenopus Conference

    The 18th International Xenopus Conference will be held virtually August 15-19, 2021.

    Regretfully, the in-person event expected to occur has been cancelled.

    Abstract deadline: May 30th.

    Registration now open.

    Early bird registration deadline: July 31.

    Check the conference website to view the updated program.

    Official conference website.

    See the conference brochure.

     

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  • The Wnt/PCP formin Daam1 drives cell-cell adhesion during nephron development

    Krneta-Stankic et al. show that the Wnt/PCP formin Daam1 regulates cytoskeletal membrane dynamics and E-cadherin localization within developing nephrons.

     

    Published in Cell Reports.

     

     

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  • Xenopus, from basic biology to disease models in the genomic era

    An upcoming book to be released by CRC Press.

    Edited by Abraham Fainsood and Sally A. Moody.

     

    Click here to view a PDF flier containing the table of contents. 

     

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  • Three-dimensional folding dynamics of the Xenopus tropicalis genome

    Animal interphase chromosomes are organized into topologically associating domains (TADs). Niu et al. show that X. tropicalis is a powerful model for chromosome architecture analysis suggesting that chromatin remodeling plays an essential role in de novo TAD establishment. Published in Nature Genetics.

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  • ModelMatcher

    a new registry connecting Scientists and Clinicians

    • Use your Xenopus expertise to help patients and clinicians
    • Boost the clinical significance of your Xenopus research
    • Share your genes of interest
    • Xenopus research is supported by ModelMatcher


    Visit ModelMatcher to register

    Click the link: https://www.modelmatcher.net

     

     

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  • The Scf/Kit pathway implements self-organised epithelial patterning

    Social distancing is no mystery to Xenopus cells! Chuyen et al. report how thousands of multiciliated cells distribute into a regular pattern in the developing epidermis, through homotypic repulsion and homing at intercalation sites. Published in Developmental Cell.

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  • Biallelic variants in COPB1 cause a novel, severe intellectual disability syndrome with cataracts and variable microcephaly

    CRISPR/Cas9-mediated mutation of Coat protein complex 1 (COPI) subunit COPB1 in X. tropicalis recapitulates features of the human "coatopathy" syndrome including microcephaly and cataracts. Published in Genome Medicine.

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  • Genesis Special Issue: Aquatic Models of Developmental Disorders

    Published February 2021

     

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  • Phenotypes on Xenbase

    The latest release of Xenbase includes the ability to search for Phenotypes.

     

    Click here to go to the Phenotype search page.

     

    Click here to find details on executing a Phenotype search.

     

    Click here to find details on the Xenopus Phenotype Ontology (XPO).

     

     

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  • Xenopus tropicalis v10 genome

    - available to BLAST

    - view on JBrowse

     

    99.86% of the genome mapped to chromosomes
    ~4500 new and refined models, 18% not present in trop v9.1

     

    Click here to view the release document.

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  • 2020 Xenopus White Paper

    The 2020 Xenopus Community White Paper is now available!

    PIs: Please reference the White Paper in your NIH grant proposals and contact your program officers.

    Download the 2020 Xenopus White Paper:

    Word Document

    PDF

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  • 18th International Xenopus Conference

    The 18th International Xenopus Conference will be held virtually August 15-19, 2021.

    Regretfully, the in-person event expected to occur has been cancelled.

    Abstract deadline: May 30th.

    Registration now open.

    Early bird registration deadline: July 31.

    Check the conference website to view the updated program.

    Official conference website.

    See the conference brochure.

     

    Read More...

Xenopus is an essential vertebrate model system for biomedical research

  • Share 83% human disease genes
  • Ease of genomic manipulation
  • Large eggs and embryos with rapid external development
  • Ease of housing
  • Produce hardy eggs year-round
  • Learn more about Xenopus


The Xenopus model organism knowledgebase
Xenbase is a web-accessible resource that integrates all the diverse biological, genomic, genotype and phenotype data available from Xenopus research. Learn more about Xenbase.