Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
J Physiol
2005 Jan 01;562Pt 1:235-44. doi: 10.1113/jphysiol.2004.071266.
Show Gene links
Show Anatomy links
Pancreatic two P domain K+ channels TALK-1 and TALK-2 are activated by nitric oxide and reactive oxygen species.
Duprat F
,
Girard C
,
Jarretou G
,
Lazdunski M
.
???displayArticle.abstract???
This study firstly shows with in situ hybridization on human pancreas that TALK-1 and TALK-2, two members of the 2P domain potassium channel (K(2P)) family, are highly and specifically expressed in the exocrine pancreas and absent in Langherans islets. On the contrary, expression of TASK-2 in mouse pancreas is found both in the exocrine pancreas and in the Langherans islets. This study also shows that TALK-1 and TALK-2 channels, expressed in Xenopus oocytes, are strongly and specifically activated by nitric oxide (obtained with a mixture of sodium nitroprussate (SNP) and dithiothreitol (DTT)), superoxide anion (obtained with xanthine and xanthine oxidase) and singlet oxygen (obtained upon photoactivation of rose bengal, and with chloramine T). Other nitric oxide and reactive oxygen species (NOS and ROS) donors, as well as reducing conditions were found to be ineffective on TALK-1, TALK-2 and TASK-2 (sin-1, angeli's salt, SNP alone, tBHP, H(2)O(2), and DTT). These results suggest that, in the exocrine pancreas, specific members of the NOS and ROS families could act as endogenous modulators of TALK channels with a role in normal secretion as well as in disease states such as acute pancreatitis and apoptosis.
Bang,
TREK-2, a new member of the mechanosensitive tandem-pore K+ channel family.
2000, Pubmed
Bang,
TREK-2, a new member of the mechanosensitive tandem-pore K+ channel family.
2000,
Pubmed
Bates,
Nitric oxide generation from nitroprusside by vascular tissue. Evidence that reduction of the nitroprusside anion and cyanide loss are required.
1991,
Pubmed
Beckman,
Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly.
1996,
Pubmed
Chavez,
TWIK-2, a new weak inward rectifying member of the tandem pore domain potassium channel family.
1999,
Pubmed
,
Xenbase
Dabrowski,
Role of oxidative stress in the pathogenesis of caerulein-induced acute pancreatitis.
1999,
Pubmed
Dascal,
The use of Xenopus oocytes for the study of ion channels.
1987,
Pubmed
,
Xenbase
Decher,
Characterization of TASK-4, a novel member of the pH-sensitive, two-pore domain potassium channel family.
2001,
Pubmed
,
Xenbase
Duprat,
TASK, a human background K+ channel to sense external pH variations near physiological pH.
1997,
Pubmed
,
Xenbase
Fink,
Cloning, functional expression and brain localization of a novel unconventional outward rectifier K+ channel.
1996,
Pubmed
,
Xenbase
Furchgott,
The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine.
1980,
Pubmed
Girard,
Genomic and functional characteristics of novel human pancreatic 2P domain K(+) channels.
2001,
Pubmed
,
Xenbase
Hughes,
Relationships between nitric oxide, nitroxyl ion, nitrosonium cation and peroxynitrite.
1999,
Pubmed
Hughes,
Synthesis, chemistry, and applications of nitroxyl ion releasers sodium trioxodinitrate or Angeli's salt and Piloty's acid.
1999,
Pubmed
Jiang,
Regulation of cloned cardiac L-type calcium channels by cGMP-dependent protein kinase.
2000,
Pubmed
,
Xenbase
Kang,
Single-channel properties and pH sensitivity of two-pore domain K+ channels of the TALK family.
2004,
Pubmed
Kim,
TASK-3, a new member of the tandem pore K(+) channel family.
2000,
Pubmed
Kim,
TASK-5, a new member of the tandem-pore K(+) channel family.
2001,
Pubmed
Konturek,
Nitric oxide in pancreatic secretion and hormone-induced pancreatitis in rats.
1994,
Pubmed
Lauritzen,
K+-dependent cerebellar granule neuron apoptosis. Role of task leak K+ channels.
2003,
Pubmed
Leidenheimer,
Effect of PKG activation on recombinant GABAA receptors.
1996,
Pubmed
,
Xenbase
Lesage,
TWIK-1, a ubiquitous human weakly inward rectifying K+ channel with a novel structure.
1996,
Pubmed
,
Xenbase
Lesage,
Molecular and functional properties of two-pore-domain potassium channels.
2000,
Pubmed
Lesage,
Cloning and expression of human TRAAK, a polyunsaturated fatty acids-activated and mechano-sensitive K(+) channel.
2000,
Pubmed
Lohmann,
Distinct and specific functions of cGMP-dependent protein kinases.
1997,
Pubmed
Miller,
Preconditioning for cardioprotection against ischemia reperfusion injury: the roles of nitric oxide, reactive oxygen species, heat shock proteins, reactive hyperemia and antioxidants--a mini review.
2001,
Pubmed
Molero,
Nitric oxide modulates pancreatic basal secretion and response to cerulein in the rat: effects in acute pancreatitis.
1995,
Pubmed
Patel,
The TREK two P domain K+ channels.
2002,
Pubmed
Petersen,
Stimulus-secretion coupling: cytoplasmic calcium signals and the control of ion channels in exocrine acinar cells.
1992,
Pubmed
Rajan,
THIK-1 and THIK-2, a novel subfamily of tandem pore domain K+ channels.
2001,
Pubmed
,
Xenbase
Reyes,
Cloning and expression of a novel pH-sensitive two pore domain K+ channel from human kidney.
1998,
Pubmed
Salinas,
Cloning of a new mouse two-P domain channel subunit and a human homologue with a unique pore structure.
1999,
Pubmed
,
Xenbase
Sano,
A novel two-pore domain K+ channel, TRESK, is localized in the spinal cord.
2003,
Pubmed
Schmid,
Inwardly rectifying, voltage-dependent and resting potassium currents in rat pancreatic acinar cells in primary culture.
1997,
Pubmed
Schulz,
Oxidative stress in acute pancreatitis.
1999,
Pubmed
Simon,
Role of reactive oxygen species (ROS) in apoptosis induction.
2000,
Pubmed
Skarnes,
Gene trapping methods for the identification and functional analysis of cell surface proteins in mice.
2000,
Pubmed
Stamler,
Biochemistry of nitric oxide and its redox-activated forms.
1992,
Pubmed
Stief,
Singlet oxygen (1O(2)) disrupts platelet aggregates.
2001,
Pubmed
Talley,
TASK-1, a two-pore domain K+ channel, is modulated by multiple neurotransmitters in motoneurons.
2000,
Pubmed
Warth,
Proximal renal tubular acidosis in TASK2 K+ channel-deficient mice reveals a mechanism for stabilizing bicarbonate transport.
2004,
Pubmed
Wrenn,
Nitric oxide participates in the regulation of pancreatic acinar cell secretion.
1994,
Pubmed
