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Nat Struct Mol Biol
2010 Aug 01;178:926-8. doi: 10.1038/nsmb0810-926.
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A new nuclease member of the FAN club.
Huang M, D'Andrea AD.
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To cope with the life-threatening crisis of a DNA interstrand cross-link (ICL), human cells must invoke the Fanconi anemia (FA) DNA repair pathway. The FA pathway is a multistep repair process, requiring multiple nucleolytic incisions and translesion DNA synthesis. Recent work from four laboratories has identified a novel FA-associated nuclease, FAN1, that binds directly to monoubiquitinated FANCD2, resolving a decade-long puzzle regarding the function of this FANCD2 modification.
Bienko,
Ubiquitin-binding domains in Y-family polymerases regulate translesion synthesis.
2005,
Pubmed Ciccia,
Structural and functional relationships of the XPF/MUS81 family of proteins.
2008,
Pubmed Cohn,
A UAF1-containing multisubunit protein complex regulates the Fanconi anemia pathway.
2007,
Pubmed D'Andrea,
The Fanconi anaemia/BRCA pathway.
2003,
Pubmed Dronkert,
Disruption of mouse SNM1 causes increased sensitivity to the DNA interstrand cross-linking agent mitomycin C.
2000,
Pubmed Fekairi,
Human SLX4 is a Holliday junction resolvase subunit that binds multiple DNA repair/recombination endonucleases.
2009,
Pubmed Garcia-Higuera,
Interaction of the Fanconi anemia proteins and BRCA1 in a common pathway.
2001,
Pubmed Hazrati,
Human SNM1A suppresses the DNA repair defects of yeast pso2 mutants.
2008,
Pubmed Kadyrov,
Endonucleolytic function of MutLalpha in human mismatch repair.
2006,
Pubmed Kim,
Inactivation of murine Usp1 results in genomic instability and a Fanconi anemia phenotype.
2009,
Pubmed Knipscheer,
The Fanconi anemia pathway promotes replication-dependent DNA interstrand cross-link repair.
2009,
Pubmed
,
Xenbase Kratz,
Deficiency of FANCD2-associated nuclease KIAA1018/FAN1 sensitizes cells to interstrand crosslinking agents.
2010,
Pubmed MacKay,
Identification of KIAA1018/FAN1, a DNA repair nuclease recruited to DNA damage by monoubiquitinated FANCD2.
2010,
Pubmed Moldovan,
How the fanconi anemia pathway guards the genome.
2009,
Pubmed Muñoz,
Coordination of structure-specific nucleases by human SLX4/BTBD12 is required for DNA repair.
2009,
Pubmed Pace,
Ku70 corrupts DNA repair in the absence of the Fanconi anemia pathway.
2010,
Pubmed Patel,
Fanconi anemia and DNA replication repair.
2007,
Pubmed Räschle,
Mechanism of replication-coupled DNA interstrand crosslink repair.
2008,
Pubmed
,
Xenbase Singh,
MHF1-MHF2, a histone-fold-containing protein complex, participates in the Fanconi anemia pathway via FANCM.
2010,
Pubmed Smogorzewska,
A genetic screen identifies FAN1, a Fanconi anemia-associated nuclease necessary for DNA interstrand crosslink repair.
2010,
Pubmed Smogorzewska,
Identification of the FANCI protein, a monoubiquitinated FANCD2 paralog required for DNA repair.
2007,
Pubmed Svendsen,
Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required for DNA repair.
2009,
Pubmed Vaz,
Mutation of the RAD51C gene in a Fanconi anemia-like disorder.
2010,
Pubmed Wang,
Emergence of a DNA-damage response network consisting of Fanconi anaemia and BRCA proteins.
2007,
Pubmed Wood,
A ubiquitin-binding motif in the translesion DNA polymerase Rev1 mediates its essential functional interaction with ubiquitinated proliferating cell nuclear antigen in response to DNA damage.
2007,
Pubmed Yan,
A histone-fold complex and FANCM form a conserved DNA-remodeling complex to maintain genome stability.
2010,
Pubmed Yang,
RAD18-dependent recruitment of SNM1A to DNA repair complexes by a ubiquitin-binding zinc finger.
2010,
Pubmed
