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Nitric oxide as a putative retinal axon pathfinding and target recognition cue in Xenopus laevis.
Berman S
,
Morris A
.
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Nitric oxide (NO) is an atypical neurotransmitter synthesized by the enzyme nitric oxide synthase (NOS) during many stages of the Xenopus laevis life cycle. This research investigates whether the gas NO is involved in axon guidance, the neurodevelopmental process in which axons travel through the brain to their appropriate target locations to form functional neural circuitry. Through immunocytochemistry and direct labeling of the NO gas with a fluorescent dye, we have found that NOS expression corresponds spatiotemporally with the beginning of retinal axon innervation of the optic tectum in X. laevis. Our function-blocking studies in which NO is chemically inhibited suggest that NO may be necessary for correct pathfinding and targeting, evidenced by qualitative widening of the optic tract and aberrant target innervation.
Atkinson-Leadbeater,
Dynamic expression of axon guidance cues required for optic tract development is controlled by fibroblast growth factor signaling.
2010, Pubmed,
Xenbase
Atkinson-Leadbeater,
Dynamic expression of axon guidance cues required for optic tract development is controlled by fibroblast growth factor signaling.
2010,
Pubmed
,
Xenbase
Brüning,
Localization of nitric oxide synthase in the brain of the frog, Xenopus laevis.
1996,
Pubmed
,
Xenbase
Chien,
Axonal guidance from retina to tectum in embryonic Xenopus.
1994,
Pubmed
,
Xenbase
Cline,
NMDA receptor agonist and antagonists alter retinal ganglion cell arbor structure in the developing frog retinotectal projection.
1990,
Pubmed
Cogen,
Nitric oxide modulates retinal ganglion cell axon arbor remodeling in vivo.
2000,
Pubmed
,
Xenbase
Ditlevsen,
Cyclic guanosine monophosphate signalling pathway plays a role in neural cell adhesion molecule-mediated neurite outgrowth and survival.
2007,
Pubmed
Erskine,
The retinal ganglion cell axon's journey: insights into molecular mechanisms of axon guidance.
2007,
Pubmed
Gaikwad,
Neuronal nitric oxide synthase in the olfactory system, forebrain, pituitary and retina of the adult teleost Clarias batrachus.
2009,
Pubmed
Giraldi-Guimarães,
A critical survey on nitric oxide synthase expression and nitric oxide function in the retinotectal system.
2007,
Pubmed
Gordon,
Xenopus sonic hedgehog guides retinal axons along the optic tract.
2010,
Pubmed
,
Xenbase
Harris,
Early events in the embryogenesis of the vertebrate visual system: cellular determination and pathfinding.
1990,
Pubmed
Harris,
Growth cones of developing retinal cells in vivo, on culture surfaces, and in collagen matrices.
1985,
Pubmed
,
Xenbase
Knipp,
A developmental study of enteric neuron migration in the grasshopper using immunological probes.
2009,
Pubmed
Knowles,
Formation of nitric oxide from L-arginine in the central nervous system: a transduction mechanism for stimulation of the soluble guanylate cyclase.
1989,
Pubmed
Kojima,
Fluorescent Indicators for Imaging Nitric Oxide Production.
1999,
Pubmed
López,
Ontogeny of NADPH diaphorase/nitric oxide synthase reactivity in the brain of Xenopus laevis.
2002,
Pubmed
,
Xenbase
Mann,
New views on retinal axon development: a navigation guide.
2004,
Pubmed
,
Xenbase
Rentería,
Nitric oxide in the retinotectal system: a signal but not a retrograde messenger during map refinement and segregation.
1999,
Pubmed
,
Xenbase
Schmidt,
Axon guidance proteins: novel therapeutic targets for ALS?
2009,
Pubmed
Sheng,
DAF-FM (4-amino-5-methylamino-2',7'-difluorofluorescein) diacetate detects impairment of agonist-stimulated nitric oxide synthesis by elevated glucose in human vascular endothelial cells: reversal by vitamin C and L-sepiapterin.
2005,
Pubmed
Tojima,
The nitric oxide-cGMP pathway controls the directional polarity of growth cone guidance via modulating cytosolic Ca2+ signals.
2009,
Pubmed
Trimm,
Nitric oxide acts as a slow-down and search signal in developing neurites.
2004,
Pubmed
Van Wagenen,
Regulation of neuronal growth cone filopodia by nitric oxide depends on soluble guanylyl cyclase.
2001,
Pubmed
Van Wagenen,
Regulation of neuronal growth cone filopodia by nitric oxide.
1999,
Pubmed
Vincent,
Nitric oxide neurons and neurotransmission.
2010,
Pubmed
Williams,
Correlation of nitric oxide synthase expression with changing patterns of axonal projections in the developing visual system.
1994,
Pubmed
Wizenmann,
Extracellular Engrailed participates in the topographic guidance of retinal axons in vivo.
2009,
Pubmed
,
Xenbase
Wu,
The role of nitric oxide in development of topographic precision in the retinotectal projection of chick.
2001,
Pubmed
Zou,
Morphogens as conserved axon guidance cues.
2007,
Pubmed
