Georges SA , Giebler HA , Cole PA , Luger K , Laybourn PJ , Nyborg JK .

CA 87540 NCI NIH HHS , GM 62437 NIGMS NIH HHS , R01 CA055035-10A1 NCI NIH HHS , CA 87540 NCI NIH HHS , R01 CA055035 NCI NIH HHS , R37 GM062437 NIGMS NIH HHS , R01 CA087540 NCI NIH HHS , R01 GM062437 NIGMS NIH HHS

Adya, Distinct regions in human T-cell lymphotropic virus type I tax mediate interactions with activator protein CREB and basal transcription factors. 1995, Pubmed

Adya, Distinct regions in human T-cell lymphotropic virus type I tax mediate interactions with activator protein CREB and basal transcription factors. 1995, Pubmed
Alcasabas, Mrc1 transduces signals of DNA replication stress to activate Rad53. 2001, Pubmed
Alexandru, Phosphorylation of the cohesin subunit Scc1 by Polo/Cdc5 kinase regulates sister chromatid separation in yeast. 2001, Pubmed
Allen, The SAD1/RAD53 protein kinase controls multiple checkpoints and DNA damage-induced transcription in yeast. 1994, Pubmed
An, Selective requirements for histone H3 and H4 N termini in p300-dependent transcriptional activation from chromatin. 2002, Pubmed , Xenbase
An, Direct association of p300 with unmodified H3 and H4 N termini modulates p300-dependent acetylation and transcription of nucleosomal templates. 2003, Pubmed , Xenbase
Anderson, Identification of poly(ADP-ribose) polymerase as a transcriptional coactivator of the human T-cell leukemia virus type 1 Tax protein. 2000, Pubmed
Annunziato, Role of histone acetylation in the assembly and modulation of chromatin structures. 2000, Pubmed
Asahara, Dual roles of p300 in chromatin assembly and transcriptional activation in cooperation with nucleosome assembly protein 1 in vitro. 2002, Pubmed
Asahara, Chromatin-dependent cooperativity between constitutive and inducible activation domains in CREB. 2001, Pubmed
Bannister, The CBP co-activator is a histone acetyltransferase. , Pubmed
Bex, Differential transcriptional activation by human T-cell leukemia virus type 1 Tax mutants is mediated by distinct interactions with CREB binding protein and p300. 1998, Pubmed
Biggins, The conserved protein kinase Ipl1 regulates microtubule binding to kinetochores in budding yeast. 1999, Pubmed
Boyle, Phosphopeptide mapping and phosphoamino acid analysis by two-dimensional separation on thin-layer cellulose plates. 1991, Pubmed
Breeden, Cell cycle-specific expression of the SWI4 transcription factor is required for the cell cycle regulation of HO transcription. 1991, Pubmed
Byeon, Solution structure of the yeast Rad53 FHA2 complexed with a phosphothreonine peptide pTXXL: comparison with the structures of FHA2-pYXL and FHA1-pTXXD complexes. 2002, Pubmed
Carruthers, The core histone N termini function independently of linker histones during chromatin condensation. 2000, Pubmed
Chan, p300/CBP proteins: HATs for transcriptional bridges and scaffolds. 2001, Pubmed
Chehab, Chk2/hCds1 functions as a DNA damage checkpoint in G(1) by stabilizing p53. 2000, Pubmed
Chirinos, Repressive effect on oligonucleosome transcription of the core histone tail domains. 1998, Pubmed
Dallas, Characterization of monoclonal antibodies raised against p300: both p300 and CBP are present in intracellular TBP complexes. 1997, Pubmed
Dirick, Roles and regulation of Cln-Cdc28 kinases at the start of the cell cycle of Saccharomyces cerevisiae. 1995, Pubmed
Dover, Methylation of histone H3 by COMPASS requires ubiquitination of histone H2B by Rad6. 2002, Pubmed
Durocher, The FHA domain. 2002, Pubmed
Durocher, The FHA domain is a modular phosphopeptide recognition motif. 1999, Pubmed
Durocher, The molecular basis of FHA domain:phosphopeptide binding specificity and implications for phospho-dependent signaling mechanisms. 2002, Pubmed
Emili, Dynamic interaction of DNA damage checkpoint protein Rad53 with chromatin assembly factor Asf1. 2001, Pubmed
Emili, MEC1-dependent phosphorylation of Rad9p in response to DNA damage. 1998, Pubmed
Falck, The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis. 2001, Pubmed
Fletcher, Core histone tail domains mediate oligonucleosome folding and nucleosomal DNA organization through distinct molecular mechanisms. 1995, Pubmed
Foiani, DNA damage checkpoints and DNA replication controls in Saccharomyces cerevisiae. 2000, Pubmed
Franklin, Transactivation by the human T-cell leukemia virus Tax protein is mediated through enhanced binding of activating transcription factor-2 (ATF-2) ATF-2 response and cAMP element-binding protein (CREB). 1993, Pubmed
Galy, Nuclear pore complexes in the organization of silent telomeric chromatin. 2000, Pubmed
Garcia-Ramirez, Modulation of chromatin folding by histone acetylation. 1995, Pubmed
Gardner, RAD53, DUN1 and PDS1 define two parallel G2/M checkpoint pathways in budding yeast. 1999, Pubmed
Georges, p300-mediated tax transactivation from recombinant chromatin: histone tail deletion mimics coactivator function. 2002, Pubmed , Xenbase
Gerald, Robust G1 checkpoint arrest in budding yeast: dependence on DNA damage signaling and repair. 2003, Pubmed
Giebler, Anchoring of CREB binding protein to the human T-cell leukemia virus type 1 promoter: a molecular mechanism of Tax transactivation. 1997, Pubmed
Gilbert, Budding yeast Rad9 is an ATP-dependent Rad53 activating machine. 2001, Pubmed
Godde, The amino-terminal tails of the core histones and the translational position of the TATA box determine TBP/TFIIA association with nucleosomal DNA. 1995, Pubmed , Xenbase
Goodman, CBP/p300 in cell growth, transformation, and development. 2000, Pubmed
Goren, The amino terminus of Tax is required for interaction with the cyclic AMP response element binding protein. 1995, Pubmed
Grenon, Checkpoint activation in response to double-strand breaks requires the Mre11/Rad50/Xrs2 complex. 2001, Pubmed
Hansen, Structure and function of the core histone N-termini: more than meets the eye. 1998, Pubmed
Hansen, Conformational dynamics of the chromatin fiber in solution: determinants, mechanisms, and functions. 2002, Pubmed
Harrod, An exposed KID-like domain in human T-cell lymphotropic virus type 1 Tax is responsible for the recruitment of coactivators CBP/p300. 1998, Pubmed
Harrod, p300 and p300/cAMP-responsive element-binding protein associated factor interact with human T-cell lymphotropic virus type-1 Tax in a multi-histone acetyltransferase/activator-enhancer complex. 2000, Pubmed
Hernández, Transcriptional inhibitory role of the tail domains of histone (H3 x H4)2 tetramers. 1998, Pubmed
Hirano, The ABCs of SMC proteins: two-armed ATPases for chromosome condensation, cohesion, and repair. 2002, Pubmed
Hirao, DNA damage-induced activation of p53 by the checkpoint kinase Chk2. 2000, Pubmed
Ho, Regulation of transcription at the Saccharomyces cerevisiae start transition by Stb1, a Swi6-binding protein. 1999, Pubmed
Hu, Regulation of the Bub2/Bfa1 GAP complex by Cdc5 and cell cycle checkpoints. 2001, Pubmed
Hu, Asf1 links Rad53 to control of chromatin assembly. 2001, Pubmed
Ito, Drosophila NAP-1 is a core histone chaperone that functions in ATP-facilitated assembly of regularly spaced nucleosomal arrays. 1996, Pubmed
Ito, ACF consists of two subunits, Acf1 and ISWI, that function cooperatively in the ATP-dependent catalysis of chromatin assembly. 1999, Pubmed
Iyer, Genomic binding sites of the yeast cell-cycle transcription factors SBF and MBF. 2001, Pubmed
Jelinsky, Global response of Saccharomyces cerevisiae to an alkylating agent. 1999, Pubmed
Jenuwein, Translating the histone code. 2001, Pubmed
Jiang, PCAF interacts with tax and stimulates tax transactivation in a histone acetyltransferase-independent manner. 1999, Pubmed
Kashanchi, The coactivator CBP stimulates human T-cell lymphotrophic virus type I Tax transactivation in vitro. 1998, Pubmed
Kasten, Identification of the Saccharomyces cerevisiae genes STB1-STB5 encoding Sin3p binding proteins. 1998, Pubmed
Kelly, Type B histone acetyltransferase Hat1p participates in telomeric silencing. 2000, Pubmed
Kim, Involvement of the cohesin protein, Smc1, in Atm-dependent and independent responses to DNA damage. 2002, Pubmed
Kim, Substrate specificities and identification of putative substrates of ATM kinase family members. 2000, Pubmed
Kimzey, Specific regions of contact between human T-cell leukemia virus type I Tax protein and DNA identified by photocross-linking. 1998, Pubmed
Krajewski, Modulation of the higher-order folding of chromatin by deletion of histone H3 and H4 terminal domains. 1996, Pubmed
Kraus, p300 and estrogen receptor cooperatively activate transcription via differential enhancement of initiation and reinitiation. 1998, Pubmed
Kraus, Biochemical analysis of distinct activation functions in p300 that enhance transcription initiation with chromatin templates. 1999, Pubmed
Kundu, Activator-dependent transcription from chromatin in vitro involving targeted histone acetylation by p300. 2000, Pubmed
Kunkel, Rapid and efficient site-specific mutagenesis without phenotypic selection. 1985, Pubmed
Kwok, Control of cAMP-regulated enhancers by the viral transactivator Tax through CREB and the co-activator CBP. 1996, Pubmed
Kwok, Nuclear protein CBP is a coactivator for the transcription factor CREB. 1994, Pubmed
Lau, HATs off: selective synthetic inhibitors of the histone acetyltransferases p300 and PCAF. 2000, Pubmed
Lee, hCds1-mediated phosphorylation of BRCA1 regulates the DNA damage response. 2000, Pubmed
Lemasson, Human T-cell leukemia virus type I tax repression of p73beta is mediated through competition for the C/H1 domain of CBP. 2001, Pubmed
Lenzmeier, The tax protein-DNA interaction is essential for HTLV-I transactivation in vitro. 1999, Pubmed
Lenzmeier, Human T-cell leukemia virus type 1 Tax requires direct access to DNA for recruitment of CREB binding protein to the viral promoter. 1998, Pubmed
Lowndes, Sensing and responding to DNA damage. 2000, Pubmed
Lu, Acetylation of nucleosomal histones by p300 facilitates transcription from tax-responsive human T-cell leukemia virus type 1 chromatin template. 2002, Pubmed
Luger, Characterization of nucleosome core particles containing histone proteins made in bacteria. 1997, Pubmed , Xenbase
Luger, Preparation of nucleosome core particle from recombinant histones. 1999, Pubmed , Xenbase
Lundblad, The human T-cell leukemia virus-1 transcriptional activator Tax enhances cAMP-responsive element-binding protein (CREB) binding activity through interactions with the DNA minor groove. 1998, Pubmed
Manning, p300 forms a stable, template-committed complex with chromatin: role for the bromodomain. 2001, Pubmed
Marti, DNA mismatch repair and mutation avoidance pathways. 2002, Pubmed
Matsuoka, Linkage of ATM to cell cycle regulation by the Chk2 protein kinase. 1998, Pubmed
McInerny, A novel Mcm1-dependent element in the SWI4, CLN3, CDC6, and CDC47 promoters activates M/G1-specific transcription. 1997, Pubmed
Mendenhall, Regulation of Cdc28 cyclin-dependent protein kinase activity during the cell cycle of the yeast Saccharomyces cerevisiae. 1999, Pubmed
Näär, Chromatin, TAFs, and a novel multiprotein coactivator are required for synergistic activation by Sp1 and SREBP-1a in vitro. 1998, Pubmed
Nash, Multisite phosphorylation of a CDK inhibitor sets a threshold for the onset of DNA replication. 2002, Pubmed
Nasmyth, Disseminating the genome: joining, resolving, and separating sister chromatids during mitosis and meiosis. 2002, Pubmed
Ogryzko, The transcriptional coactivators p300 and CBP are histone acetyltransferases. 1996, Pubmed
Okada, Differential requirements for activation of integrated and transiently transfected human T-cell leukemia virus type 1 long terminal repeat. 2002, Pubmed
O'Neill, Determination of substrate motifs for human Chk1 and hCds1/Chk2 by the oriented peptide library approach. 2002, Pubmed
Pellicioli, Regulation of Saccharomyces Rad53 checkpoint kinase during adaptation from DNA damage-induced G2/M arrest. 2001, Pubmed
Polach, Effects of core histone tail domains on the equilibrium constants for dynamic DNA site accessibility in nucleosomes. 2000, Pubmed
Polesskaya, CBP/p300 and muscle differentiation: no HAT, no muscle. 2001, Pubmed
Protacio, Effects of histone tail domains on the rate of transcriptional elongation through a nucleosome. 2000, Pubmed
Robzyk, Rad6-dependent ubiquitination of histone H2B in yeast. 2000, Pubmed
Rupes, Checking cell size in yeast. 2002, Pubmed
Sanchez, Regulation of RAD53 by the ATM-like kinases MEC1 and TEL1 in yeast cell cycle checkpoint pathways. 1996, Pubmed
Sanchez, Control of the DNA damage checkpoint by chk1 and rad53 protein kinases through distinct mechanisms. 1999, Pubmed
Sandell, Loss of a yeast telomere: arrest, recovery, and chromosome loss. 1993, Pubmed
Schiltz, Overlapping but distinct patterns of histone acetylation by the human coactivators p300 and PCAF within nucleosomal substrates. 1999, Pubmed
Schwartz, Rad9 phosphorylation sites couple Rad53 to the Saccharomyces cerevisiae DNA damage checkpoint. 2002, Pubmed
Scoggin, The oncoprotein Tax binds the SRC-1-interacting domain of CBP/p300 to mediate transcriptional activation. 2001, Pubmed
Shieh, The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites. 2000, Pubmed
Sidorova, Precocious S-phase entry in budding yeast prolongs replicative state and increases dependence upon Rad53 for viability. 2002, Pubmed
Sidorova, Analysis of the SWI4/SWI6 protein complex, which directs G1/S-specific transcription in Saccharomyces cerevisiae. 1993, Pubmed
Sidorova, Cell cycle-regulated phosphorylation of Swi6 controls its nuclear localization. 1996, Pubmed
Sidorova, Rad53-dependent phosphorylation of Swi6 and down-regulation of CLN1 and CLN2 transcription occur in response to DNA damage in Saccharomyces cerevisiae. 1997, Pubmed
Siede, RAD9-dependent G1 arrest defines a second checkpoint for damaged DNA in the cell cycle of Saccharomyces cerevisiae. 1993, Pubmed
Siede, Characterization of G1 checkpoint control in the yeast Saccharomyces cerevisiae following exposure to DNA-damaging agents. 1995, Pubmed
Sterner, Acetylation of histones and transcription-related factors. 2000, Pubmed
Strahl, The language of covalent histone modifications. 2000, Pubmed
Stuart, CLN3, not positive feedback, determines the timing of CLN2 transcription in cycling cells. 1995, Pubmed
Sun, Spk1/Rad53 is regulated by Mec1-dependent protein phosphorylation in DNA replication and damage checkpoint pathways. 1996, Pubmed
Sun, Ubiquitination of histone H2B regulates H3 methylation and gene silencing in yeast. 2002, Pubmed
Sun, Rad53 FHA domain associated with phosphorylated Rad9 in the DNA damage checkpoint. 1998, Pubmed
Tse, Hybrid trypsinized nucleosomal arrays: identification of multiple functional roles of the H2A/H2B and H3/H4 N-termini in chromatin fiber compaction. 1997, Pubmed
Uhlmann, Sister-chromatid separation at anaphase onset is promoted by cleavage of the cohesin subunit Scc1. 1999, Pubmed
van Leeuwen, Dot1p modulates silencing in yeast by methylation of the nucleosome core. 2002, Pubmed
Vialard, The budding yeast Rad9 checkpoint protein is subjected to Mec1/Tel1-dependent hyperphosphorylation and interacts with Rad53 after DNA damage. 1998, Pubmed
Vitolo, The H3-H4 N-terminal tail domains are the primary mediators of transcription factor IIIA access to 5S DNA within a nucleosome. 2000, Pubmed , Xenbase
Wang, Pds1 phosphorylation in response to DNA damage is essential for its DNA damage checkpoint function. 2001, Pubmed
Yan, Molecular interactions between the coactivator CBP and the human T-cell leukemia virus Tax protein. 1998, Pubmed
Yazdi, SMC1 is a downstream effector in the ATM/NBS1 branch of the human S-phase checkpoint. 2002, Pubmed
Yoshida, Multiple viral strategies of HTLV-1 for dysregulation of cell growth control. 2001, Pubmed
Yuan, Solution structures of two FHA1-phosphothreonine peptide complexes provide insight into the structural basis of the ligand specificity of FHA1 from yeast Rad53. 2002, Pubmed
Zhao, Human T-cell lymphotropic virus type I (HTLV-I) transcriptional activator, Tax, enhances CREB binding to HTLV-I 21-base-pair repeats by protein-protein interaction. 1992, Pubmed
Zhao, Interaction of the human T-cell lymphotrophic virus type I (HTLV-I) transcriptional activator Tax with cellular factors that bind specifically to the 21-base-pair repeats in the HTLV-I enhancer. 1991, Pubmed
Zheng, SPK1 is an essential S-phase-specific gene of Saccharomyces cerevisiae that encodes a nuclear serine/threonine/tyrosine kinase. 1993, Pubmed
Zhou, The DNA damage response: putting checkpoints in perspective. 2000, Pubmed