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Am J Physiol Renal Physiol
2019 Feb 01;3162:F263-F273. doi: 10.1152/ajprenal.00573.2017.
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Cloning, function, and localization of human, canine, and Drosophila ZIP10 (SLC39A10), a Zn2+ transporter.
Landry GM
,
Furrow E
,
Holmes HL
,
Hirata T
,
Kato A
,
Williams P
,
Strohmaier K
,
Gallo CJR
,
Chang M
,
Pandey MK
,
Jiang H
,
Bansal A
,
Franz MC
,
Montalbetti N
,
Alexander MP
,
Cabrero P
,
Dow JAT
,
DeGrado TR
,
Romero MF
.
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Zinc (Zn2+) is the second most abundant trace element, but is considered a micronutrient, as it is a cofactor for many enzymes and transcription factors. Whereas Zn2+ deficiency can cause cognitive immune or metabolic dysfunction and infertility, excess Zn2+ is nephrotoxic. As for other ions and solutes, Zn2+ is moved into and out of cells by specific membrane transporters: ZnT, Zip, and NRAMP/DMT proteins. ZIP10 is reported to be localized at the apical membrane of renal proximal tubules in rats, where it is believed to play a role in Zn2+ import. Renal regulation of Zn2+ is of particular interest in light of growing evidence that Zn2+ may play a role in kidney stone formation. The objective of this study was to show that ZIP10 homologs transport Zn2+, as well as ZIP10, kidney localization across species. We cloned ZIP10 from dog, human, and Drosophila ( CG10006), tested clones for Zn2+ uptake in Xenopus oocytes and localized the protein in renal structures. CG10006, rather than foi (fear-of-intimacy, CG6817) is the primary ZIP10 homolog found in Drosophila Malpighian tubules. The ZIP10 antibody recognizes recombinant dog, human, and Drosophila ZIP10 proteins. Immunohistochemistry reveals that ZIP10 in higher mammals is found not only in the proximal tubule, but also in the collecting duct system. These ZIP10 proteins show Zn2+ transport. Together, these studies reveal ZIP10 kidney localization, a role in renal Zn2+ transport, and indicates that CG10006 is a Drosophila homolog of ZIP10.
Broun,
Excessive zinc ingestion. A reversible cause of sideroblastic anemia and bone marrow depression.
1990, Pubmed
Broun,
Excessive zinc ingestion. A reversible cause of sideroblastic anemia and bone marrow depression.
1990,
Pubmed
Chen,
Functional analysis of nonsynonymous single nucleotide polymorphisms in human SLC26A9.
2012,
Pubmed
,
Xenbase
Chintapalli,
Using FlyAtlas to identify better Drosophila melanogaster models of human disease.
2007,
Pubmed
Croxford,
Moderate zinc deficiency reduces testicular Zip6 and Zip10 abundance and impairs spermatogenesis in mice.
2011,
Pubmed
DeGrado,
Preparation and preliminary evaluation of 63Zn-zinc citrate as a novel PET imaging biomarker for zinc.
2014,
Pubmed
Franz,
Reassessment of the Transport Mechanism of the Human Zinc Transporter SLC39A2.
2018,
Pubmed
Franz,
Zinc transporters in prostate cancer.
2013,
Pubmed
Gaither,
Functional expression of the human hZIP2 zinc transporter.
2000,
Pubmed
Gunshin,
Cloning and characterization of a mammalian proton-coupled metal-ion transporter.
1997,
Pubmed
,
Xenbase
Hirata,
In vivo Drosophilia genetic model for calcium oxalate nephrolithiasis.
2012,
Pubmed
Huang,
The SLC30 family of zinc transporters - a review of current understanding of their biological and pathophysiological roles.
2013,
Pubmed
Jeong,
The SLC39 family of zinc transporters.
2013,
Pubmed
Kagara,
Zinc and its transporter ZIP10 are involved in invasive behavior of breast cancer cells.
2007,
Pubmed
Kaler,
Molecular cloning and functional characterization of novel zinc transporter rZip10 (Slc39a10) involved in zinc uptake across rat renal brush-border membrane.
2007,
Pubmed
Kambe,
The Physiological, Biochemical, and Molecular Roles of Zinc Transporters in Zinc Homeostasis and Metabolism.
2015,
Pubmed
Kong,
Maternally-derived zinc transporters ZIP6 and ZIP10 drive the mammalian oocyte-to-egg transition.
2014,
Pubmed
Li,
NADPH oxidase-2 mediates zinc deficiency-induced oxidative stress and kidney damage.
2017,
Pubmed
Lichten,
MTF-1-mediated repression of the zinc transporter Zip10 is alleviated by zinc restriction.
2011,
Pubmed
Lichten,
Mammalian zinc transporters: nutritional and physiologic regulation.
2009,
Pubmed
Liman,
Subunit stoichiometry of a mammalian K+ channel determined by construction of multimeric cDNAs.
1992,
Pubmed
,
Xenbase
Mackenzie,
Divalent metal-ion transporter DMT1 mediates both H+ -coupled Fe2+ transport and uncoupled fluxes.
2006,
Pubmed
,
Xenbase
Miyai,
Zinc transporter SLC39A10/ZIP10 facilitates antiapoptotic signaling during early B-cell development.
2014,
Pubmed
Montalbetti,
Mammalian iron transporters: families SLC11 and SLC40.
2013,
Pubmed
Pal,
Association between ZIP10 gene expression and tumor aggressiveness in renal cell carcinoma.
2014,
Pubmed
Pawan,
Upregulation of Slc39a10 gene expression in response to thyroid hormones in intestine and kidney.
2007,
Pubmed
Richards,
A fly's eye view of zinc homeostasis: Novel insights into the genetic control of zinc metabolism from Drosophila.
2016,
Pubmed
Romero,
Cloning and functional expression of rNBC, an electrogenic Na(+)-HCO3- cotransporter from rat kidney.
1998,
Pubmed
,
Xenbase
Ryu,
Zinc transporters ZnT1 (Slc30a1), Zip8 (Slc39a8), and Zip10 (Slc39a10) in mouse red blood cells are differentially regulated during erythroid development and by dietary zinc deficiency.
2008,
Pubmed
Sciortino,
Cation and voltage dependence of rat kidney electrogenic Na(+)-HCO(-)(3) cotransporter, rkNBC, expressed in oocytes.
1999,
Pubmed
,
Xenbase
Terhzaz,
Mechanism and function of Drosophila capa GPCR: a desiccation stress-responsive receptor with functional homology to human neuromedinU receptor.
2012,
Pubmed
Xiao,
What can flies tell us about zinc homeostasis?
2016,
Pubmed
Yin,
Functional studies of Drosophila zinc transporters reveal the mechanism for zinc excretion in Malpighian tubules.
2017,
Pubmed
