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Corno AF
,
Zhou Z
,
Uppu SC
,
Huang S
,
Marino B
,
Milewicz DM
,
Salazar JD
.
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The heart of the African clawed frog has a double-inlet and single-outlet ventricle supporting systemic and pulmonary circulations via a truncus, and a lifespan of 25-30 years. We sought to understand the unique cardiac anatomic and physiologic characteristics, with balanced circulation and low metabolic rate, by comparing the basic anatomy structures with focused echocardiography and cardiac magnetic resonance imaging. Twenty-four adult female African clawed frogs were randomly subjected to anatomic dissection (n = 4), echocardiography (n = 10), and cardiac magnetic resonance (n = 10). All anatomical features were confirmed and compared with echocardiography and cardiac magnetic resonance imaging. The main characteristics of the cardiovascular circulation in frogs are the following: Intact interatrial septum, with two separate atrio-ventricular valves, preventing atrial mixing of oxygenated and desaturated blood. Single spongiform ventricular cavity, non-conducive for homogeneous mixing. Single outlet with a valve-like mobile spiral structure, actively streaming into systemic and pulmonary arteries. Intact interatrial septum, spongiform ventricle, and valve-like spiral in the conus arteriosus are likely responsible for balanced systemic and pulmonary circulation in frogs, in spite of double-inlet and single-outlet ventricle.
Ammash,
Survival into adulthood of patients with unoperated single ventricle.
1996, Pubmed
Ammash,
Survival into adulthood of patients with unoperated single ventricle.
1996,
Pubmed
Bartlett,
Echocardiographic assessment of cardiac morphology and function in Xenopus.
2010,
Pubmed
,
Xenbase
Buchhorn,
Pathogenetic mechanisms of venous congestion after the Fontan procedure.
2001,
Pubmed
Burggren,
Amphibians as animal models for laboratory research in physiology.
2007,
Pubmed
,
Xenbase
CHAMBERS,
Cor triloculare biatriatum. Survival to adult life.
1961,
Pubmed
Christoffels,
Chamber formation and morphogenesis in the developing mammalian heart.
2000,
Pubmed
Claessen,
Heart Rate Reserve in Fontan Patients: Chronotropic Incompetence or Hemodynamic Limitation?
2019,
Pubmed
Corno,
Univentricular heart: can we alter the natural history?
1982,
Pubmed
de Leval,
Four decades of Fontan palliation.
2010,
Pubmed
Dennis,
Clinical Outcomes in Adolescents and Adults After the Fontan Procedure.
2018,
Pubmed
Driedzic,
Energy metabolism and contractility in ectothermic vertebrate hearts: hypoxia, acidosis, and low temperature.
1994,
Pubmed
Duncan,
Pulmonary arteriovenous malformations after cavopulmonary anastomosis.
2003,
Pubmed
Gewillig,
The Fontan circulation after 45 years: update in physiology.
2016,
Pubmed
Grande,
Nodal signalling is involved in left-right asymmetry in snails.
2009,
Pubmed
Haberich,
The functional separation of venous and arterial blood in the univentricular frog heart.
1965,
Pubmed
Hicks,
The physiological and evolutionary significance of cardiovascular shunting patterns in reptiles.
2002,
Pubmed
Hillman,
Net cardiac shunts in anuran amphibians: physiology or physics?
2014,
Pubmed
Knight,
Use of frog ventricle to examine mechanical and electrical activity of heart.
1989,
Pubmed
Lagerstrand,
Effects of calcium and pH on the mechanical performance of heart muscle in the frog, Rana temporaria, during anoxia and subsequent recovery.
1980,
Pubmed
Lamers,
Cardiac septation: a late contribution of the embryonic primary myocardium to heart morphogenesis.
2002,
Pubmed
Marcelletti,
Inferior vena cava-pulmonary artery extracardiac conduit. A new form of right heart bypass.
1990,
Pubmed
Marino,
Spiral pattern: universe, normal heart, and complex congenital defects.
2003,
Pubmed
Marino,
Transposition of the great arteries in asplenia and polysplenia phenotypes.
2002,
Pubmed
Moorman,
Cardiac chamber formation: development, genes, and evolution.
2003,
Pubmed
Narkewicz,
Hepatic dysfunction following the Fontan procedure.
2003,
Pubmed
Poterucha,
Survival and outcomes of patients with unoperated single ventricle.
2016,
Pubmed
Puelz,
A computational study of the Fontan circulation with fenestration or hepatic vein exclusion.
2017,
Pubmed
Pundi,
Sudden cardiac death and late arrhythmias after the Fontan operation.
2017,
Pubmed
Restaino,
Long-term survival in a case of unoperated single ventricle.
2004,
Pubmed
Rijnberg,
Energetics of Blood Flow in Cardiovascular Disease: Concept and Clinical Implications of Adverse Energetics in Patients With a Fontan Circulation.
2018,
Pubmed
SHARMA,
The circulatory mechanism and anatomy of the heart of the frog, Rana pipiens.
1961,
Pubmed
Sylva,
Development of the human heart.
2014,
Pubmed
Van Praagh,
Terminology of congenital heart disease. Glossary and commentary.
1977,
Pubmed
Versacci,
The heart and shell. Anatomical and genetic similarities.
2011,
Pubmed
