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Genes Dev
2002 Feb 15;164:421-6. doi: 10.1101/gad.219202.
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Mutual genetic antagonism involving GLI3 and dHAND prepatterns the vertebrate limb budmesenchyme prior to SHH signaling.
te Welscher P
,
Fernandez-Teran M
,
Ros MA
,
Zeller R
.
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The bHLH transcription factor dHAND is required for establishment of SHH signaling by the limb bud organizer in posteriormesenchyme, a step crucial to development of vertebrate paired appendages. We show that the transcriptional repressor GLI3 restricts dHAND expression to posteriormesenchyme prior to activation of SHH signaling in mouse limb buds. dHAND, in turn, excludes anterior genes such as Gli3 and Alx4 from posteriormesenchyme. Furthermore, genetic interaction of GLI3 and dHAND directs establishment of the SHH/FGF signaling feedback loop by restricting the BMP antagonist GREMLIN posteriorly. These interactions polarize the nascent limb bud mesenchyme prior to SHH signaling.
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11850405
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