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Visual experience regulates metabotropic glutamate receptor-mediated plasticity of AMPA receptor synaptic transmission by homer1a induction.
Van Keuren-Jensen K
,
Cline HT
.
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Brief metabotropic glutamate receptor (mGluR) activation leads to plasticity of AMPA receptor (AMPAR) synaptic transmission. To test whether mGluR-mediated plasticity of AMPAR transmission is influenced by recent neuronal activity, we manipulated visual activity in Xenopus laevis tadpoles in vivo. We compared mGluR-mediated plasticity of AMPAR transmission in optic tectal cells of tadpoles with low levels of previous synaptic activity (overnight in the dark) to transmission in neurons from animals after 4 h of constant visual stimulation. mGluR-mediated plasticity of AMPA transmission was significantly decreased in neurons with recent activity. We tested the role of the activity-regulated mGluR scaffolding protein Homer1a in modulating mGluR-mediated changes in AMPAR transmission. We found that, by changing the ratios of Homer 1a to Homer 1b in vivo, by either induction of endogenous Homer1a by visual activity or ectopic expression of Homer1a or Homer1b, we could change the direction of mGluR-mediated plasticity. This is the first evidence that mGluR-mediated changes in AMPA transmission can be regulated by Homer proteins in response to physiologically relevant stimuli.
Aizenman,
Visually driven modulation of glutamatergic synaptic transmission is mediated by the regulation of intracellular polyamines.
2002, Pubmed,
Xenbase
Aizenman,
Visually driven modulation of glutamatergic synaptic transmission is mediated by the regulation of intracellular polyamines.
2002,
Pubmed
,
Xenbase
Aizenman,
Visually driven regulation of intrinsic neuronal excitability improves stimulus detection in vivo.
2003,
Pubmed
,
Xenbase
Atwood,
Diversification of synaptic strength: presynaptic elements.
2002,
Pubmed
Beneken,
Structure of the Homer EVH1 domain-peptide complex reveals a new twist in polyproline recognition.
2000,
Pubmed
Bottai,
Synaptic activity-induced conversion of intronic to exonic sequence in Homer 1 immediate early gene expression.
2002,
Pubmed
Brakeman,
Homer: a protein that selectively binds metabotropic glutamate receptors.
1997,
Pubmed
Cantallops,
Postsynaptic CPG15 promotes synaptic maturation and presynaptic axon arbor elaboration in vivo.
2000,
Pubmed
,
Xenbase
Ehrengruber,
Homer/Vesl proteins and their roles in CNS neurons.
2004,
Pubmed
Engert,
Moving visual stimuli rapidly induce direction sensitivity of developing tectal neurons.
2002,
Pubmed
,
Xenbase
Foa,
Homer expression in the Xenopus tadpole nervous system.
2005,
Pubmed
,
Xenbase
Haas,
Single-cell electroporation for gene transfer in vivo.
2001,
Pubmed
,
Xenbase
Hennou,
Homer-1a/Vesl-1S enhances hippocampal synaptic transmission.
2003,
Pubmed
Huang,
Sustained activation of metabotropic glutamate receptor 5 and protein tyrosine phosphatases mediate the expression of (S)-3,5-dihydroxyphenylglycine-induced long-term depression in the hippocampal CA1 region.
2006,
Pubmed
Ju,
Activity-dependent regulation of dendritic synthesis and trafficking of AMPA receptors.
2004,
Pubmed
Kacharmina,
Stimulation of glutamate receptor protein synthesis and membrane insertion within isolated neuronal dendrites.
2000,
Pubmed
Kato,
Novel members of the Vesl/Homer family of PDZ proteins that bind metabotropic glutamate receptors.
1998,
Pubmed
Malinow,
AMPA receptor trafficking and synaptic plasticity.
2002,
Pubmed
Montgomery,
Discrete synaptic states define a major mechanism of synapse plasticity.
2004,
Pubmed
Moult,
Tyrosine phosphatases regulate AMPA receptor trafficking during metabotropic glutamate receptor-mediated long-term depression.
2006,
Pubmed
Nedivi,
Numerous candidate plasticity-related genes revealed by differential cDNA cloning.
1993,
Pubmed
Nedivi,
A set of genes expressed in response to light in the adult cerebral cortex and regulated during development.
1996,
Pubmed
Nosyreva,
Developmental switch in synaptic mechanisms of hippocampal metabotropic glutamate receptor-dependent long-term depression.
2005,
Pubmed
Park,
Light regulates Homer mRNA expression in the rat suprachiasmatic nucleus.
1997,
Pubmed
Sala,
Regulation of dendritic spine morphology and synaptic function by Shank and Homer.
2001,
Pubmed
Sala,
Inhibition of dendritic spine morphogenesis and synaptic transmission by activity-inducible protein Homer1a.
2003,
Pubmed
Sato,
NMDA receptor stimulation and brain-derived neurotrophic factor upregulate homer 1a mRNA via the mitogen-activated protein kinase cascade in cultured cerebellar granule cells.
2001,
Pubmed
Sin,
Dendrite growth increased by visual activity requires NMDA receptor and Rho GTPases.
2002,
Pubmed
,
Xenbase
Snyder,
Internalization of ionotropic glutamate receptors in response to mGluR activation.
2001,
Pubmed
Tadokoro,
Involvement of unique leucine-zipper motif of PSD-Zip45 (Homer 1c/vesl-1L) in group 1 metabotropic glutamate receptor clustering.
1999,
Pubmed
Tu,
Homer binds a novel proline-rich motif and links group 1 metabotropic glutamate receptors with IP3 receptors.
1998,
Pubmed
Wu,
Maturation of a central glutamatergic synapse.
1996,
Pubmed
,
Xenbase
Xiao,
Metabotropic glutamate receptor activation causes a rapid redistribution of AMPA receptors.
2001,
Pubmed
Xiao,
Homer regulates the association of group 1 metabotropic glutamate receptors with multivalent complexes of homer-related, synaptic proteins.
1998,
Pubmed
,
Xenbase
Zhou,
Reversal and stabilization of synaptic modifications in a developing visual system.
2003,
Pubmed
,
Xenbase
