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XB-ART-11785
FEBS Lett 1999 Dec 17;4633:285-8.
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Histone- and chromatin-binding activity of template activating factor-I.

Matsumoto K , Nagata K , Okuwaki M , Tsujimoto M .


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Template activating factor-I (TAF-I) is a histone-binding chromatin remodeling factor. We recently found that TAF-I is capable of mediating decondensation of Xenopus sperm chromatin by releasing sperm-specific basic proteins. Here we present evidence that TAF-I preferentially binds to histone H3 among four core histones. Immunofluorescent staining revealed that TAF-I binds to the decondensed sperm chromatin, of which protein components predominantly consist of histones H3 and H4.

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Species referenced: Xenopus
Genes referenced: set