Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
Cell October 1, 1999; 99 (1): 71-80.
Show Gene links Show Anatomy links

Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates.

Tamagnone L , Artigiani S , Chen H , He Z , Ming GI , Song H , Chedotal A , Winberg ML , Goodman CS , Poo M , Tessier-Lavigne M , Comoglio PM .

In Drosophila, plexin A is a functional receptor for semaphorin-1a. Here we show that the human plexin gene family comprises at least nine members in four subfamilies. Plexin-B1 is a receptor for the transmembrane semaphorin Sema4D (CD100), and plexin-C1 is a receptor for the GPI-anchored semaphorin Sema7A (Sema-K1). Secreted (class 3) semaphorins do not bind directly to plexins, but rather plexins associate with neuropilins, coreceptors for these semaphorins. Plexins are widely expressed: in neurons, the expression of a truncated plexin-A1 protein blocks axon repulsion by Sema3A. The cytoplasmic domain of plexins associates with a tyrosine kinase activity. Plexins may also act as ligands mediating repulsion in epithelial cells in vitro. We conclude that plexins are receptors for multiple (and perhaps all) classes of semaphorins, either alone or in combination with neuropilins, and trigger a novel signal transduction pathway controlling cell repulsion.

PubMed ID: 10520995
Article link: Cell
Grant support: [+]

Species referenced: Xenopus
Genes referenced: gnpda1 gpi plxna1 plxna2 plxna3 plxna4 plxnb1 plxnb2 plxnb3 plxnc1 plxnd1 sema3a sema4d