Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
Br J Pharmacol
1999 Oct 01;1283:667-72. doi: 10.1038/sj.bjp.0702862.
Show Gene links
Show Anatomy links
Block of human aortaKir6.1 by the vascular KATP channel inhibitor U37883A.
Surah-Narwal S
,
Xu SZ
,
McHugh D
,
McDonald RL
,
Hough E
,
Cheong A
,
Partridge C
,
Sivaprasadarao A
,
Beech DJ
.
???displayArticle.abstract???
1. A human aorta cDNA library was screened at low stringency with a rat pancreatic Kir6.1 cDNA probe and a homologue of Kir6.1 (hKir6.1) was isolated and sequenced. 2. Metabolic poisoning of Xenopus laevis oocytes with sodium azide and application of the K+ channel opener drug diazoxide induced K+ channel currents in oocytes co-injected with cRNA for hKir6.1 and hamster sulphonylurea receptor (SUR1), but not in oocytes injected with water or cRNA for hKir6.1 or SUR1 alone. 3. K+ channel currents due to hKir6.1+SUR1 or mouse Kir6.2+SUR1 were strongly inhibited by 1 microM glibenclamide. K+-current carried by hKir6.1+SUR1 was inhibited by the putative vascular-selective KATP channel inhibitor U37883A (IC50 32 microM) whereas current carried by Kir6.2+SUR1 or Shaker K+ channels was unaffected. 4. The data support the hypothesis that hKir6.1 is a component of the vascular KATP channel, although the lower sensitivity of hKir6.1+SUR1 to U37883A compared with native vascular tissues suggests the need for another factor or subunit. Furthermore, the data suggest that pharmacology of KATP channels can be determined by the pore-forming subunit as well as the sulphonylurea receptor and point to a molecular basis for the pharmacological distinction between vascular and pancreatic/cardiac KATP channels.
Aguilar-Bryan,
Toward understanding the assembly and structure of KATP channels.
1998, Pubmed
Aguilar-Bryan,
Toward understanding the assembly and structure of KATP channels.
1998,
Pubmed
Ammälä,
The sulphonylurea receptor confers diazoxide sensitivity on the inwardly rectifying K+ channel Kir6.1 expressed in human embryonic kidney cells.
1996,
Pubmed
Ashcroft,
Correlating structure and function in ATP-sensitive K+ channels.
1998,
Pubmed
Beech,
K channel activation by nucleotide diphosphates and its inhibition by glibenclamide in vascular smooth muscle cells.
1993,
Pubmed
Beech,
Actions of neurotransmitters and other messengers on Ca2+ channels and K+ channels in smooth muscle cells.
1997,
Pubmed
Edwards,
Recent advances in potassium channel modulation.
1997,
Pubmed
Edwards,
The pharmacology of ATP-sensitive potassium channels.
1993,
Pubmed
Erginel-Unaltuna,
Genomic organization and expression of KCNJ8/Kir6.1, a gene encoding a subunit of an ATP-sensitive potassium channel.
1998,
Pubmed
Grabner,
Transfer of 1,4-dihydropyridine sensitivity from L-type to class A (BI) calcium channels.
1996,
Pubmed
Guillemare,
Functional receptors in Xenopus oocytes for U-37883A, a novel ATP-sensitive K+ channel blocker: comparison with rat insulinoma cells.
1994,
Pubmed
,
Xenbase
Hockerman,
Construction of a high-affinity receptor site for dihydropyridine agonists and antagonists by single amino acid substitutions in a non-L-type Ca2+ channel.
1997,
Pubmed
Inagaki,
Cloning and functional characterization of a novel ATP-sensitive potassium channel ubiquitously expressed in rat tissues, including pancreatic islets, pituitary, skeletal muscle, and heart.
1995,
Pubmed
,
Xenbase
Inagaki,
cDNA sequence, gene structure, and chromosomal localization of the human ATP-sensitive potassium channel, uKATP-1, gene (KCNJ8).
1995,
Pubmed
Ishida-Takahashi,
Cystic fibrosis transmembrane conductance regulator mediates sulphonylurea block of the inwardly rectifying K+ channel Kir6.1.
1998,
Pubmed
Karschin,
KATP channel formation by the sulphonylurea receptors SUR1 with Kir6.2 subunits in rat dorsal vagal neurons in situ.
1998,
Pubmed
Katnik,
An ATP-sensitive potassium conductance in rabbit arterial endothelial cells.
1995,
Pubmed
Langheinrich,
Hyperpolarization of isolated capillaries from guinea-pig heart induced by K+ channel openers and glucose deprivation.
1997,
Pubmed
Ludens,
Renal and vascular effects of chemically distinct ATP-sensitive K+ channel blockers in rats.
1995,
Pubmed
Meisheri,
4-morpholinecarboximidine-N-1-adamantyl-N'-cyclohexylhydrochloride (U-37883A): pharmacological characterization of a novel antagonist of vascular ATP-sensitive K+ channel openers.
1993,
Pubmed
Quayle,
ATP-sensitive and inwardly rectifying potassium channels in smooth muscle.
1997,
Pubmed
Satoh,
Intracellular nucleotide-mediated gating of SUR/Kir6.0 complex potassium channels expressed in a mammalian cell line and its modification by pinacidil.
1998,
Pubmed
Suzuki,
Kir6.1: a possible subunit of ATP-sensitive K+ channels in mitochondria.
1997,
Pubmed
Takano,
Cytoplasmic terminus domains of Kir6.x confer different nucleotide-dependent gating on the ATP-sensitive K+ channel.
1998,
Pubmed
Yamada,
Sulphonylurea receptor 2B and Kir6.1 form a sulphonylurea-sensitive but ATP-insensitive K+ channel.
1997,
Pubmed
Zhang,
Two types of ATP-sensitive potassium channels in rat portal vein smooth muscle cells.
1996,
Pubmed
