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J Cell Biol 1999 Sep 06;1465:1005-18. doi: 10.1083/jcb.146.5.1005.
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mini spindles: A gene encoding a conserved microtubule-associated protein required for the integrity of the mitotic spindle in Drosophila.

Cullen CF , Deák P , Glover DM , Ohkura H .

We describe a new Drosophila gene, mini spindles (msps) identified in a cytological screen for mitotic mutant. Mutation in msps disrupts the structural integrity of the mitotic spindle, resulting in the formation of one or more small additional spindles in diploid cells. Nucleation of microtubules from centrosomes, metaphase alignment of chromosomes, or the focusing of spindle poles appears much less affected. The msps gene encodes a 227-kD protein with high similarity to the vertebrate microtubule-associated proteins (MAPs), human TOGp and Xenopus XMAP215, and with limited similarity to the Dis1 and STU2 proteins from fission yeast and budding yeast. Consistent with their sequence similarity, Msps protein also associates with microtubules in vitro. In the embryonic division cycles, Msps protein localizes to centrosomal regions at all mitotic stages, and spreads over the spindles during metaphase and anaphase. The absence of centrosomal staining in interphase of the cellularized embryos suggests that the interactions between Msps protein and microtubules or centrosomes may be regulated during the cell cycle.

PubMed ID: 10477755
PMC ID: PMC2169485
Article link: J Cell Biol
Grant support: [+]

Species referenced: Xenopus
Genes referenced: cdk1 ckap5 pnma2 tff3.7 tmprss13

Article Images: [+] show captions
References [+] :
Albertson, Formation of the first cleavage spindle in nematode embryos. 1984, Pubmed