XB-ART-13935Trends Genet 1998 Nov 01;1411:459-65.
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Molecular mechanisms of vertebrate left-right development.
Patterning of all tissues and organs in the vertebrate embryo occurs along the dorsoventral (DV), anteroposterior (AP), and left-right (LR) body axes. Whereas significant progress has been made in identifying the processes underlying DV and AP patterning, relatively little is known about mechanisms guiding LR development. The significant incidence of human disease conditions associated with LR laterality defects, particularly those of the cardiovascular system, underscores the importance of understanding how LR asymmetries become established in the embryo. The focus of this review is on recently identified genes that are involved in generation of vertebrate LR asymmetry, and the proposed cellular and molecular mechanisms by which they might function in initiation, propagation and interpretation of LR patterning information.
PubMed ID: 9825674
Article link: Trends Genet
Species referenced: Xenopus
Genes referenced: ctnnb1 foxa2 lefty nodal pitx2 shh sia1 tgfb1 zic3
GO keywords: heart development
Disease Ontology terms: visceral heterotaxy