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J Bioenerg Biomembr
1998 Aug 01;304:357-75. doi: 10.1023/a:1021989622656.
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Structures and functions of calcium channel beta subunits.
Birnbaumer L
,
Qin N
,
Olcese R
,
Tareilus E
,
Platano D
,
Costantin J
,
Stefani E
.
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Calcium channel beta subunits have profound effects on how alpha1 subunits perform. In this article we summarize our present knowledge of the primary structures of beta subunits as deduced from cDNAs and illustrate their different properties. Upon co-expression with alpha1 subunits, the effects of beta subunits vary somewhat between L-type and non-L-type channels mostly because the two types of channels have different responses to voltage which are affected by beta subunits, such as long-lasting prepulse facilitation of alpha1C (absent in alpha1E) and inhibition by G protein betagamma dimer of alpha1E, absent in alpha1C. One beta subunit, a brain beta2a splice variant that is palmitoylated, has several effects not seen with any of the others, and these are due to palmitoylation. We also illustrate the finding that functional expression of alpha1 in oocytes requires a beta subunit even if the final channel shows no evidence for its presence. We propose two structural models for Ca2+ channels to account for "alpha1 alone" channels seen in cells with limited beta subunit expression. In one model, beta dissociates from the mature alpha1 after proper folding and membrane insertion. Regulated channels seen upon co-expression of high levels of beta would then have subunit composition alpha1beta. In the other model, the "chaperoning" beta remains associated with the mature channel and "alpha1 alone" channels would in fact be alpha1beta channels. Upon co-expression of high levels of beta the regulated channels would have composition [alpha1beta]beta.
Artalejo,
Three types of bovine chromaffin cell Ca2+ channels: facilitation increases the opening probability of a 27 pS channel.
1991, Pubmed
Artalejo,
Three types of bovine chromaffin cell Ca2+ channels: facilitation increases the opening probability of a 27 pS channel.
1991,
Pubmed
Berrow,
Antisense depletion of beta-subunits modulates the biophysical and pharmacological properties of neuronal calcium channels.
1995,
Pubmed
Beurg,
Recovery of Ca2+ current, charge movements, and Ca2+ transients in myotubes deficient in dihydropyridine receptor beta 1 subunit transfected with beta 1 cDNA.
1997,
Pubmed
Bourinet,
The alpha 1E calcium channel exhibits permeation properties similar to low-voltage-activated calcium channels.
1996,
Pubmed
,
Xenbase
Bourinet,
Voltage-dependent facilitation of a neuronal alpha 1C L-type calcium channel.
1994,
Pubmed
,
Xenbase
Brown,
The ionic currents underlying pacemaker activity in rabbit sino-atrial node: experimental results and computer simulations.
1984,
Pubmed
Brown,
The slow inward current, isi, in the rabbit sino-atrial node investigated by voltage clamp and computer simulation.
1984,
Pubmed
Burgess,
Mutation of the Ca2+ channel beta subunit gene Cchb4 is associated with ataxia and seizures in the lethargic (lh) mouse.
1997,
Pubmed
Campbell,
Inhibition of the interaction of G protein G(o) with calcium channels by the calcium channel beta-subunit in rat neurones.
1995,
Pubmed
Castellano,
Cloning and expression of a third calcium channel beta subunit.
1993,
Pubmed
,
Xenbase
Castellano,
Cloning and expression of a neuronal calcium channel beta subunit.
1993,
Pubmed
,
Xenbase
Cens,
Coexpression of the beta2 subunit does not induce voltage-dependent facilitation of the class C L-type Ca channel.
1996,
Pubmed
,
Xenbase
Chang,
Dihydropyridine-sensitive calcium channels from skeletal muscle. II. Functional effects of differential phosphorylation of channel subunits.
1991,
Pubmed
Chien,
Roles of a membrane-localized beta subunit in the formation and targeting of functional L-type Ca2+ channels.
1995,
Pubmed
Chien,
Identification of palmitoylation sites within the L-type calcium channel beta2a subunit and effects on channel function.
1996,
Pubmed
Chin,
Genetic mapping of the mouse genes encoding the voltage-sensitive calcium channel subunits.
1995,
Pubmed
Collin,
Molecular cloning of three isoforms of the L-type voltage-dependent calcium channel beta subunit from normal human heart.
1993,
Pubmed
Collin,
Cloning, chromosomal location and functional expression of the human voltage-dependent calcium-channel beta 3 subunit.
1994,
Pubmed
,
Xenbase
Curtis,
Purification of the calcium antagonist receptor of the voltage-sensitive calcium channel from skeletal muscle transverse tubules.
1984,
Pubmed
De Jongh,
Subunits of purified calcium channels. Alpha 2 and delta are encoded by the same gene.
1990,
Pubmed
De Jongh,
Subunits of purified calcium channels: a 212-kDa form of alpha 1 and partial amino acid sequence of a phosphorylation site of an independent beta subunit.
1989,
Pubmed
De Waard,
Ca2+ channel regulation by a conserved beta subunit domain.
1994,
Pubmed
,
Xenbase
Dolphin,
Facilitation of Ca2+ current in excitable cells.
1996,
Pubmed
Dunlap,
Neurotransmitters decrease the calcium conductance activated by depolarization of embryonic chick sensory neurones.
1981,
Pubmed
Ellinor,
Functional expression of a rapidly inactivating neuronal calcium channel.
1993,
Pubmed
,
Xenbase
Fedida,
Mechanism of the use dependence of Ca2+ current in guinea-pig myocytes.
1988,
Pubmed
Flockerzi,
Purified dihydropyridine-binding site from skeletal muscle t-tubules is a functional calcium channel.
,
Pubmed
Grabner,
Cloning and functional expression of a neuronal calcium channel beta subunit from house fly (Musca domestica).
1994,
Pubmed
,
Xenbase
Gregg,
Absence of the beta subunit (cchb1) of the skeletal muscle dihydropyridine receptor alters expression of the alpha 1 subunit and eliminates excitation-contraction coupling.
1996,
Pubmed
Gregg,
Assignment of the human gene for the beta subunit of the voltage-dependent calcium channel (CACNLB1) to chromosome 17 using somatic cell hybrids and linkage mapping.
1993,
Pubmed
Gutierrez,
Protein kinase C-mediated regulation of L-type Ca channels from skeletal muscle requires phosphorylation of the alpha 1 subunit.
1994,
Pubmed
Haase,
In-vivo phosphorylation of the cardiac L-type calcium channel beta-subunit in response to catecholamines.
1996,
Pubmed
Hancock,
All ras proteins are polyisoprenylated but only some are palmitoylated.
1989,
Pubmed
Herlitze,
Modulation of Ca2+ channels by G-protein beta gamma subunits.
1996,
Pubmed
Hullin,
Calcium channel beta subunit heterogeneity: functional expression of cloned cDNA from heart, aorta and brain.
1992,
Pubmed
,
Xenbase
Ikeda,
Double-pulse calcium channel current facilitation in adult rat sympathetic neurones.
1991,
Pubmed
Ikeda,
Voltage-dependent modulation of N-type calcium channels by G-protein beta gamma subunits.
1996,
Pubmed
Iles,
Genetic mapping of the beta 1- and gamma-subunits of the human skeletal muscle L-type voltage-dependent calcium channel on chromosome 17q and exclusion as candidate genes for malignant hyperthermia susceptibility.
1993,
Pubmed
Kavalali,
Multiple voltage-dependent mechanisms potentiate calcium channel activity in hippocampal neurons.
1996,
Pubmed
Kleppisch,
Double-pulse facilitation of smooth muscle alpha 1-subunit Ca2+ channels expressed in CHO cells.
1994,
Pubmed
Lacerda,
Normalization of current kinetics by interaction between the alpha 1 and beta subunits of the skeletal muscle dihydropyridine-sensitive Ca2+ channel.
1991,
Pubmed
Lacerda,
T-type and N-type calcium channels of Xenopus oocytes: evidence for specific interactions with beta subunits.
1994,
Pubmed
,
Xenbase
Lee,
Potentiation of the calcium-channel currents of internally perfused mammalian heart cells by repetitive depolarization.
1987,
Pubmed
Mori,
Primary structure and functional expression from complementary DNA of a brain calcium channel.
1991,
Pubmed
,
Xenbase
Murakami,
Gene structure of the murine calcium channel beta3 subunit, cDNA and characterization of alternative splicing and transcription products.
1996,
Pubmed
Neely,
Potentiation by the beta subunit of the ratio of the ionic current to the charge movement in the cardiac calcium channel.
1993,
Pubmed
,
Xenbase
Neely,
Dual activation of the cardiac Ca2+ channel alpha 1C-subunit and its modulation by the beta-subunit.
1995,
Pubmed
,
Xenbase
Noble,
Voltage-dependent potentiation of the slow inward current in frog atrium.
1981,
Pubmed
Noble,
The calcium and frequency dependence of the slow inward current 'staircase' in frog atrium.
1981,
Pubmed
Noceti,
Effective gating charges per channel in voltage-dependent K+ and Ca2+ channels.
1996,
Pubmed
,
Xenbase
Olcese,
The amino terminus of a calcium channel beta subunit sets rates of channel inactivation independently of the subunit's effect on activation.
1994,
Pubmed
,
Xenbase
Olcese,
Coupling between charge movement and pore opening in vertebrate neuronal alpha 1E calcium channels.
1996,
Pubmed
,
Xenbase
Osterrieder,
Injection of subunits of cyclic AMP-dependent protein kinase into cardiac myocytes modulates Ca2+ current.
1982,
Pubmed
Park,
Chromosomal localization and neural distribution of voltage dependent calcium channel beta 3 subunit gene.
1997,
Pubmed
Perez-Reyes,
Cloning and expression of a cardiac/brain beta subunit of the L-type calcium channel.
1992,
Pubmed
,
Xenbase
Powers,
Skeletal muscle and brain isoforms of a beta-subunit of human voltage-dependent calcium channels are encoded by a single gene.
1992,
Pubmed
Pragnell,
Cloning and tissue-specific expression of the brain calcium channel beta-subunit.
1991,
Pubmed
Pragnell,
Calcium channel beta-subunit binds to a conserved motif in the I-II cytoplasmic linker of the alpha 1-subunit.
1994,
Pubmed
Qin,
Identification of a second region of the beta-subunit involved in regulation of calcium channel inactivation.
1996,
Pubmed
,
Xenbase
Qin,
Direct interaction of gbetagamma with a C-terminal gbetagamma-binding domain of the Ca2+ channel alpha1 subunit is responsible for channel inhibition by G protein-coupled receptors.
1997,
Pubmed
,
Xenbase
Ruth,
Primary structure of the beta subunit of the DHP-sensitive calcium channel from skeletal muscle.
1989,
Pubmed
Schneider,
Molecular analysis and functional expression of the human type E neuronal Ca2+ channel alpha 1 subunit.
1994,
Pubmed
,
Xenbase
Singer,
The roles of the subunits in the function of the calcium channel.
1991,
Pubmed
,
Xenbase
Soong,
Structure and functional expression of a member of the low voltage-activated calcium channel family.
1993,
Pubmed
Stea,
Localization and functional properties of a rat brain alpha 1A calcium channel reflect similarities to neuronal Q- and P-type channels.
1994,
Pubmed
,
Xenbase
Strube,
Reduced Ca2+ current, charge movement, and absence of Ca2+ transients in skeletal muscle deficient in dihydropyridine receptor beta 1 subunit.
1996,
Pubmed
Taglialatela,
Novel voltage clamp to record small, fast currents from ion channels expressed in Xenopus oocytes.
1992,
Pubmed
,
Xenbase
Tareilus,
A Xenopus oocyte beta subunit: evidence for a role in the assembly/expression of voltage-gated calcium channels that is separate from its role as a regulatory subunit.
1997,
Pubmed
,
Xenbase
Taviaux,
Assignment of human genes for beta 2 and beta 4 subunits of voltage-dependent Ca2+ channels to chromosomes 10p12 and 2q22-q23.
1997,
Pubmed
Tsunoo,
Block of calcium channels by enkephalin and somatostatin in neuroblastoma-glioma hybrid NG108-15 cells.
1986,
Pubmed
Wei,
Increase in Ca2+ channel expression by deletions at the amino terminus of the cardiac alpha 1C subunit.
1996,
Pubmed
,
Xenbase
Wei,
Heterologous regulation of the cardiac Ca2+ channel alpha 1 subunit by skeletal muscle beta and gamma subunits. Implications for the structure of cardiac L-type Ca2+ channels.
1991,
Pubmed
,
Xenbase
Williams,
Structure and functional expression of alpha 1, alpha 2, and beta subunits of a novel human neuronal calcium channel subtype.
1992,
Pubmed
,
Xenbase
Witcher,
Association of native Ca2+ channel beta subunits with the alpha 1 subunit interaction domain.
1995,
Pubmed
Yatani,
Stable expression and coupling of cardiac L-type Ca2+ channels with beta 1-adrenoceptors.
1995,
Pubmed
Zamponi,
Nickel block of a family of neuronal calcium channels: subtype- and subunit-dependent action at multiple sites.
1996,
Pubmed
,
Xenbase
Zhang,
Multiple structural elements in voltage-dependent Ca2+ channels support their inhibition by G proteins.
1996,
Pubmed
,
Xenbase
Zygmunt,
Stimulation-dependent facilitation of the high threshold calcium current in guinea-pig ventricular myocytes.
1990,
Pubmed
