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Science 2005 Aug 26;3095739:1373-6. doi: 10.1126/science.1115964.
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Spatial coordination of spindle assembly by chromosome-mediated signaling gradients.

Caudron M , Bunt G , Bastiaens P , Karsenti E .

During cell division, chromosomes are distributed to daughter cells by the mitotic spindle. This system requires spatial cues to reproducibly self-organize. We report that such cues are provided by chromosome-mediated interaction gradients between the small guanosine triphosphatase (GTPase) Ran and importin-beta. This produces activity gradients that determine the spatial distribution of microtubule nucleation and stabilization around chromosomes and that are essential for the self-organization of microtubules into a bipolar spindle.

PubMed ID: 16123300
Article link: Science

Species referenced: Xenopus laevis
Genes referenced: ran

References :
Clarke, Cell biology. A gradient signal orchestrates the mitotic spindle. 2005, Pubmed, Xenbase