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Development 1997 Jun 01;12412:2325-34. doi: 10.1242/dev.124.12.2325.
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Bmp-4 acts as a morphogen in dorsoventral mesoderm patterning in Xenopus.

Dosch R , Gawantka V , Delius H , Blumenstock C , Niehrs C .

The marginal zone is a ring of tissue that gives rise to a characteristic dorsoventral pattern of mesoderm in amphibian embryos. Bmp-4 is thought to play an important role in specifying ventral mesodermal fate. Here we show (1) that different doses of Bmp-4 are sufficient to pattern four distinct mesodermal cell types and to pattern gene expression in the early gastrula marginal zone into three domains, (2) that there is a graded requirement for a Bmp signal in mesodermal patterning, and (3) that Bmp-4 has long-range activity which can become graded in the marginal zone by the antagonizing action of noggin. The results argue that Bmp-4 acts as a morphogen in dorsoventral patterning of mesoderm.

PubMed ID: 9199359
Article link: Development

Species referenced: Xenopus
Genes referenced: bmp4 chrd.1 myf5 myod1 nog smad1 ventx1 ventx1.2 ventx2 ventx2.2

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