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Cell 1997 Mar 21;886:757-66. doi: 10.1016/s0092-8674(00)81922-4.
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Frzb, a secreted protein expressed in the Spemann organizer, binds and inhibits Wnt-8.

Wang S , Krinks M , Lin K , Luyten FP , Moos M .

We isolated a Xenopus homolog of Frzb, a newly described protein containing an amino-terminal Frizzled motif. It dorsalized Xenopus embryos and was expressed in the Spemann organizer during early gastrulation. Unlike Frizzled proteins, endogenous Frzb was soluble. Frzb was secretable and could act across cell boundaries. In several functional assays, Frzb antagonized Xwnt-8, a proposed ventralizing factor with an expression pattern complementary to that of Frzb. Furthermore, Frzb blocked induction of MyoD, an action reported recently for a dominant-negative Xwnt-8. Frzb coimmunoprecipitated with Wnt proteins, providing direct biochemical evidence for Frzb-Wnt interactions. These observations implicate Frzb in axial patterning and support the concept that Frzb binds and inactivates Xwnt-8 during gastrulation, preventing inappropriate ventral signaling in developing dorsal tissues.

PubMed ID: 9118219
Article link: Cell

Species referenced: Xenopus
Genes referenced: admp fgf2 frzb myc myod1 nodal3.2 post prl.1 sia1 src tbxt wnt8a

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