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J Biol Chem 1996 Nov 29;27148:30524-8.
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Subunit stoichiometry of a heteromultimeric G protein-coupled inward-rectifier K+ channel.

Silverman SK , Lester HA , Dougherty DA .

We investigated the stoichiometry of the heteromultimeric G protein-coupled inward-recitfier K+ channel (GIRK) formed from GIRK1 and GIRK4 subunits. Multimeric GIRK constructs with several concatenated channel subunits were expressed in Xenopus oocytes. Coexpression of various trimeric constructs with different monomers clearly showed that the functional channel has stoichiometry (GIRK1)2(GIRK4)2. Efforts to establish a preferred arrangement of subunits around the channel pore suggest that more than one arrangement may be viable.

PubMed ID: 8940021
Article link: J Biol Chem
Grant support: [+]

Species referenced: Xenopus laevis
Genes referenced: kcnj3 kcnj5