XB-ART-17847Nature 1996 Aug 15;3826592:595-601. doi: 10.1038/382595a0.
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Cerberus is a head-inducing secreted factor expressed in the anterior endoderm of Spemann''s organizer.
An abundant cDNA enriched in Spemann''s organizer, cerberus, was isolated by differential screening. It encodes a secreted protein that is expressed in the anterior endomesoderm. Microinjection of cerberus mRNA into Xenopus embryos induces ectopic heads, and duplicated hearts and livers. The results suggest a role for a molecule expressed in the anterior endoderm in the induction of head structures in the vertebrate embryo.
PubMed ID: 8757128
Article link: Nature
Species referenced: Xenopus
Genes referenced: cer1