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Proc Natl Acad Sci U S A 1994 Oct 25;9122:10255-9.
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A truncated bone morphogenetic protein receptor affects dorsal-ventral patterning in the early Xenopus embryo.

Suzuki A , Thies RS , Yamaji N , Song JJ , Wozney JM , Murakami K , Ueno N .

Bone morphogenetic proteins (BMPs), which are members of the transforming growth factor beta (TGF-beta) superfamily, have been implicated in bone formation and the regulation of early development. To better understand the roles of BMPs in Xenopus laevis embryogenesis, we have cloned a cDNA coding for a serine/threonine kinase receptor that binds BMP-2 and BMP-4. To analyze its function, we attempted to block the BMP signaling pathway in Xenopus embryos by using a dominant-negative mutant of the BMP receptor. When the mutant receptor lacking the putative serine/threonine kinase domain was expressed in ventral blastomeres of Xenopus embryos, these blastomeres were respecified to dorsal mesoderm, eventually resulting in the formation of a secondary body axis. These findings suggest that endogenous BMP-2 and BMP-4 are involved in the dorsal-ventral specification in the embryo and that ventral fate requires induction rather than resulting from an absence of dorsal specification.

PubMed ID: 7937936
PMC ID: PMC44998
Article link: Proc Natl Acad Sci U S A

Species referenced: Xenopus laevis
Genes referenced: alk bmp2 bmp4 bmpr1a bmpr1b gsc post tbxt tgfb1

Article Images: [+] show captions
References [+] :
Asashima, Presence of activin (erythroid differentiation factor) in unfertilized eggs and blastulae of Xenopus laevis. 1991, Pubmed, Xenbase